{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:21:16Z","timestamp":1778199676106,"version":"3.51.4"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,6,6]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Our aim was to investigate the effectiveness of montelukast in recurrently wheezy infants.<\/jats:p><jats:p>We randomised 113, 6\u201324-month-old children with recurrent wheezing to receive either placebo or montelukast daily for an 8-week period. The primary end-point was symptom-free days. The secondary aims were to evaluate the effect of montelukast on rescue medication, on lung function, airway responsiveness and exhaled nitric oxide fraction (<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>). Clinical response and<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>were determined, the functional residual capacity (FRC) and specific airway conductance (sG<jats:sub>aw<\/jats:sub>) were measured using an infant whole-body plethysmograph, the maximal flow at functional residual capacity (<jats:italic>V<\/jats:italic>\u2032<jats:sub>max,FRC<\/jats:sub>) was recorded using the squeeze technique and airway responsiveness was evaluated by performing a dosimetric methacholine challenge test.<\/jats:p><jats:p>There was no significant difference in changes in weekly symptom-free days between the montelukast and the placebo group (3.1\u20133.7 days<jats:italic>versus<\/jats:italic>2.7\u20133.1 days, p = 0.965). No significant differences were detected in the secondary end-points,<jats:italic>i.e.<\/jats:italic>use of rescue medication, FRC, s<jats:italic>G<\/jats:italic><jats:sub>aw<\/jats:sub>,<jats:italic>V<\/jats:italic>\u2032<jats:sub>max,FRC<\/jats:sub>,<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>or airway responsiveness between groups.<\/jats:p><jats:p>Montelukast therapy did not influence the number of symptom-free days, use of rescue medication, lung function, airway responsiveness or airway inflammation in recurrently wheezy, very young children<jats:italic>.<\/jats:italic><\/jats:p>","DOI":"10.1183\/09031936.00173411","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T16:17:21Z","timestamp":1342196241000},"page":"664-670","source":"Crossref","is-referenced-by-count":23,"title":["The effect of montelukast on respiratory symptoms and lung function in wheezy infants"],"prefix":"10.1183","volume":"41","author":[{"given":"Anna S.","family":"Pelkonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Malmstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Sarna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Kajosaari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Klemola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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