{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:33:02Z","timestamp":1788885182938,"version":"build-2803163510"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,1,11]]},"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>We hypothesised that hypocretin (orexin) plays a role in the determination of ventilatory chemosensitivity. 130 patients with narcolepsy\u2013cataplexy (mean\u00b1<jats:sc>sd<\/jats:sc>age 20\u00b110 yrs, 69% male) and 117 controls (22\u00b16.9 yrs, 62% male) were recruited and tested for human leukocyte antigen (HLA)-DQB1*0602 status, hyperoxia hypercapnic (change in minute ventilation (\u03b4<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>)\/carbon dioxide tension (\u03b4<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>) L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>) and hypoxic (\u03b4<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>\/change in arterial oxygen saturation measured by probe oximetry (\u03b4<jats:italic>S<\/jats:italic><jats:sub>p,O<jats:sub>2<\/jats:sub><\/jats:sub>) L\u00b7min<jats:sup>\u22121<\/jats:sup>per %<jats:italic>S<\/jats:italic><jats:sub>p,O<jats:sub>2<\/jats:sub><\/jats:sub>) responsiveness, and by spirometry. Hypocretin deficiency was determined either by measures of cerebrospinal fluid hypocretin-1 (37 patients) or by positive HLA-DQB1*0602 status. All patients and 49% of controls underwent polysomnography and multiple sleep latency testing. Despite similar spirometric values, patients had a higher apnoea\/hypopnoea index (AHI) (2.8\u00b15.4<jats:italic>versus<\/jats:italic>0.8\u00b11.6 h<jats:sup>\u22121<\/jats:sup>; p = 0.03) and lower minimal oxygen saturation during sleep (87%\u00b17<jats:italic>versus<\/jats:italic>91\u00b14%; p = 0.0002), independent of age, sex and body mass index. Patients had depressed hypoxic responsiveness (0.13\u00b10.09<jats:italic>versus<\/jats:italic>0.19\u00b10.13 L\u00b7min<jats:sup>\u22121<\/jats:sup>per %<jats:italic>S<\/jats:italic><jats:sub>p,O<jats:sub>2<\/jats:sub><\/jats:sub>; p&lt;0.0001), independent of AHI, but hypercapnic responsiveness did not differ. Examined by HLA status, positive (26 out of 117) controls had lower hypoxic but similar hypercapnic responsiveness than those marker-negative (0.13\u00b10.08<jats:italic>versus<\/jats:italic>0.20\u00b10.14 L\u00b7min<jats:sup>\u22121<\/jats:sup>per %<jats:italic>S<\/jats:italic><jats:sub>p,O<jats:sub>2<\/jats:sub><\/jats:sub>; p&lt;0.0001). Thus, a lower hypoxic responsiveness in the narcolepsy\u2013cataplexy group is a result of DQB1*0602 status rather than the clinical features of disease.<\/jats:p>","DOI":"10.1183\/09031936.00174609","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T02:53:20Z","timestamp":1264733600000},"page":"577-583","source":"Crossref","is-referenced-by-count":39,"title":["Ventilatory chemoresponsiveness, narcolepsy\u2013cataplexy and human leukocyte antigen DQB1*0602 status"],"prefix":"10.1183","volume":"36","author":[{"given":"F.","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mignot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.C.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.X.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Z.","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.Y.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.C.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.P.","family":"Strohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2010,1,28]]},"reference":[{"key":"2024102020120712000_36.3.577.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(03)00048-X"},{"key":"2024102020120712000_36.3.577.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00132-8"},{"key":"2024102020120712000_36.3.577.3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00914.2004"},{"key":"2024102020120712000_36.3.577.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.05.032"},{"key":"2024102020120712000_36.3.577.5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.autneu.2006.02.021","article-title":"Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice","volume":"126\u2013127","author":"Zhang","year":"2006","journal-title":"Auton Neurosci"},{"key":"2024102020120712000_36.3.577.6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00679.2006"},{"key":"2024102020120712000_36.3.577.7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00075.2007"},{"key":"2024102020120712000_36.3.577.8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00919.2007"},{"key":"2024102020120712000_36.3.577.9","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1553"},{"key":"2024102020120712000_36.3.577.10","doi-asserted-by":"publisher","DOI":"10.1038\/79690"},{"key":"2024102020120712000_36.3.577.11","doi-asserted-by":"publisher","DOI":"10.1086\/318799"},{"key":"2024102020120712000_36.3.577.12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/sleep\/9.1.250","article-title":"Sleep apnea in narcolepsy","volume":"9","author":"Chokroverty","year":"1986","journal-title":"Sleep"},{"key":"2024102020120712000_36.3.577.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.08.010"},{"key":"2024102020120712000_36.3.577.14","unstructured":"The International Classification of Sleep Disorders: Diagnosticand Coding Manual, 2nd Edn. 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