{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:15:28Z","timestamp":1740460528475,"version":"3.37.3"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,6,23]]},"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>We have previously shown that children (average age 9\u2005yrs) with mildly elevated obstructive apnoea\/hypopnoea indices (OAHI) retained CO<jats:sub>2<\/jats:sub>at rest. Here, we report the results of a 6-yr follow-up study on 14 children from that study.<\/jats:p><jats:p>Minute ventilation (<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>) and end-tidal CO<jats:sub>2<\/jats:sub>partial pressure (<jats:italic>P<\/jats:italic><jats:sub>ET,CO<jats:sub>2<\/jats:sub><\/jats:sub>) were measured during hypercapnic challenge.<\/jats:p><jats:p>OAHI decreased from 7.5\u00b14.7\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>at age 9\u2005yrs to 2.5\u00b11.8\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>at age 15\u2005yrs (p&lt;0.001), despite an increase in body mass index from 20\u00b14.6\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>to 26\u00b15.7\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>(p&lt;0.0001). Eupneic<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>increased from 4.1\u00b10.31\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7m<jats:sup>\u22122<\/jats:sup>to 5.9\u00b10.4\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7m<jats:sup>\u22122<\/jats:sup>(p&lt;0.01), while<jats:italic>P<\/jats:italic><jats:sub>ET,CO<jats:sub>2<\/jats:sub><\/jats:sub>fell from 44.1\u00b10.8 to 33\u00b11.0\u2005mmHg (p&lt;0.001). The<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>\u2013<jats:italic>P<\/jats:italic><jats:sub>ET,CO<jats:sub>2<\/jats:sub><\/jats:sub>obtained during hypercapnia was left shifted, such that<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>at a<jats:italic>P<\/jats:italic><jats:sub>ET,CO<jats:sub>2<\/jats:sub><\/jats:sub>of 50\u2005mmHg increased from 24\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>at age 9\u2005yrs to 36\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>at age 15\u2005yrs. Central respiratory drive did not change.<\/jats:p><jats:p>We hypothesise that somatic growth of the pharynx coupled with a regression of tonsillar tissue mass with age leads to enlargement of the upper airway lumen, a reduction in airway resistance and increased respiratory airflow at a given level of ventilatory drive.<\/jats:p>","DOI":"10.1183\/09031936.00178408","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T02:32:16Z","timestamp":1246588336000},"page":"124-131","source":"Crossref","is-referenced-by-count":0,"title":["Control of breathing in children with mild sleep apnoea: a 6-year follow-up study"],"prefix":"10.1183","volume":"35","author":[{"given":"A.","family":"Rice","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Costy-Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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