{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:09:50Z","timestamp":1774120190245,"version":"3.50.1"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,3,16]]},"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Migraine with aura (MA) is associated with cardiac right-to-left shunt. We prospectively studied the association between pulmonary arteriovenous malformations (PAVMs) and MA in hereditary haemorrhagic telangiectasia (HHT).<\/jats:p><jats:p>All 220 consecutive HHT patients who underwent high-resolution chest computed tomography for PAVM screening were included prospectively. Prior to screening, a structured validated headache questionnaire was completed by 196 patients (57% female; mean\u00b1sd age 44.6\u00b115.2\u2005yrs). Two neurologists diagnosed migraine according to the International Headache Society Criteria.<\/jats:p><jats:p>A PAVM was present in 70 (36%) patients. The prevalence of MA was 24% in the presence of a PAVM compared with 6% in the absence of a PAVM (OR 4.6, 95% CI 1.84\u201311.2; p\u200a=\u200a0.001), and MA was an independent predictor for the presence of PAVM using multivariate analysis (OR 3.6, 95% CI 1.21\u201310.5; p\u200a=\u200a0.02). A PAVM was present in 68% of the patients with MA compared with 32% in the non-migraine controls (OR 4.6, 95% CI 1.84\u201311.2; p\u200a=\u200a0.001), and a PAVM was an independent predictor for MA using multivariate analysis (OR 3.0, 95% CI 1.00\u20139.20; p\u200a=\u200a0.05).<\/jats:p><jats:p>In conclusion, PAVMs are associated with MA in HHT patients.<\/jats:p>","DOI":"10.1183\/09031936.00179008","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T00:45:36Z","timestamp":1238114736000},"page":"882-887","source":"Crossref","is-referenced-by-count":36,"title":["Pulmonary arteriovenous malformations associated with migraine with aura"],"prefix":"10.1183","volume":"34","author":[{"given":"M. C.","family":"Post","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. W. F.","family":"van Gent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W. M.","family":"Plokker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. J.","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Kelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Mager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. T.","family":"Overtoom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"Schonewille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Thijs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Snijder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2009,3,26]]},"reference":[{"key":"2024102019534800000_34.4.882.1","first-page":"S17","volume":"44","year":"1994","journal-title":"Neurology"},{"key":"2024102019534800000_34.4.882.2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.537"},{"key":"2024102019534800000_34.4.882.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.896"},{"key":"2024102019534800000_34.4.882.4","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000179800.73706.20"},{"key":"2024102019534800000_34.4.882.5","doi-asserted-by":"publisher","DOI":"10.1159\/000134011"},{"key":"2024102019534800000_34.4.882.6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.8.714"},{"key":"2024102019534800000_34.4.882.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2485"},{"key":"2024102019534800000_34.4.882.8","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.035451"},{"key":"2024102019534800000_34.4.882.9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"key":"2024102019534800000_34.4.882.10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1148\/radiology.182.3.1535899","volume":"182","year":"1992","journal-title":"Radiology"},{"key":"2024102019534800000_34.4.882.11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi170"},{"key":"2024102019534800000_34.4.882.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2003.00824.x"},{"key":"2024102019534800000_34.4.882.13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.537"},{"key":"2024102019534800000_34.4.882.14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090406"},{"key":"2024102019534800000_34.4.882.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280610"},{"key":"2024102019534800000_34.4.882.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01024.x"},{"key":"2024102019534800000_34.4.882.17","doi-asserted-by":"publisher","DOI":"10.1042\/CS20000231"},{"key":"2024102019534800000_34.4.882.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00291.x"},{"key":"2024102019534800000_34.4.882.19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)91156-H"},{"key":"2024102019534800000_34.4.882.20","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1148\/radiology.169.3.3186989","volume":"169","year":"1988","journal-title":"Radiology"},{"key":"2024102019534800000_34.4.882.21","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1212\/WNL.55.7.959","volume":"55","year":"2000","journal-title":"Neurology"},{"key":"2024102019534800000_34.4.882.22","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194257.75559.b0"},{"key":"2024102019534800000_34.4.882.23","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20931"},{"key":"2024102019534800000_34.4.882.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03160-3"},{"key":"2024102019534800000_34.4.882.25","first-page":"11","volume":"2","year":"1988","journal-title":"Lancet"},{"key":"2024102019534800000_34.4.882.26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/01.STR.32.4.877","volume":"32","year":"2001","journal-title":"Stroke"},{"key":"2024102019534800000_34.4.882.27","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.4.427"},{"key":"2024102019534800000_34.4.882.28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38302.504063.8F"},{"key":"2024102019534800000_34.4.882.29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00323.x"},{"key":"2024102019534800000_34.4.882.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1991.hed3108509.x"},{"key":"2024102019534800000_34.4.882.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1993.hed3303145.x"},{"key":"2024102019534800000_34.4.882.32","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025700"},{"key":"2024102019534800000_34.4.882.33","first-page":"463","volume":"140","year":"2006","journal-title":"Am J Med Genet A"},{"key":"2024102019534800000_34.4.882.34","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.8.1221"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00179008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:25:52Z","timestamp":1740378352000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00179008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,26]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,9,30]]},"published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1183\/09031936.00179008"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00179008","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,26]]}}}