{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:44:59Z","timestamp":1790675099922,"version":"4.1.0"},"reference-count":48,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,3,26]]},"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>We sought to investigate the characteristics, survival and risk factors for mortality in Chinese patients with connective tissue disease (CTD)-associated pulmonary arterial hypertension (APAH) in modern therapy era.<\/jats:p>\n                  <jats:p>129 consecutive adult patients who visited one of three referral centres in China with a diagnosis of CTD-APAH confirmed by right heart catheterisation during the previous 5 years were enrolled. The end-point was all-cause death or data censoring.<\/jats:p>\n                  <jats:p>Systemic lupus erythematosus was the most common underlying CTD (49%) and systemic sclerosis just accounted for 6% in this cohort. The overall survival at 1 and 3 years was 92% and 80%, respectively. Pericardial effusion, a shorter 6-min walk distance, lower mixed venous oxygen saturation, higher pulmonary vascular resistance (PVR) and alkaline phosphatase (ALP), and lower total cholesterol levels were all associated with a higher risk of death among the study population. Higher PVR and ALP were independent predictors of mortality.<\/jats:p>\n                  <jats:p>In conclusion, unlike in western patients, systemic lupus erythematosus is the most common underlying disease in Chinese patients with CTD-APAH. The survival of Chinese patients with CTD-APAH in the modern treatment era is similar to that in western countries. Elevated PVR and ALP are independent risk factors for poor outcomes.<\/jats:p>","DOI":"10.1183\/09031936.00182813","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T01:37:15Z","timestamp":1399081035000},"page":"963-972","source":"Crossref","is-referenced-by-count":141,"title":["Connective tissue disease-associated pulmonary arterial hypertension in Chinese patients"],"prefix":"10.1183","volume":"44","author":[{"given":"Yan-Jie","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Cheng","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"key":"2024102022463123000_44.4.963.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0260"},{"key":"2024102022463123000_44.4.963.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200806-953OC"},{"key":"2024102022463123000_44.4.963.3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306072311"},{"key":"2024102022463123000_44.4.963.4","doi-asserted-by":"publisher","DOI":"10.1191\/0961203306lu2305xx"},{"key":"2024102022463123000_44.4.963.5","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310374305"},{"key":"2024102022463123000_44.4.963.6","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834ff2e8"},{"key":"2024102022463123000_44.4.963.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.05.003"},{"key":"2024102022463123000_44.4.963.8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh253"},{"key":"2024102022463123000_44.4.963.9","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.553736"},{"key":"2024102022463123000_44.4.963.10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"2024102022463123000_44.4.963.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"2024102022463123000_44.4.963.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"2024102022463123000_44.4.963.13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"2024102022463123000_44.4.963.14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/art.1780330811","article-title":"The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis","volume":"33","author":"Arend","year":"1990","journal-title":"Arthritis Rheum"},{"key":"2024102022463123000_44.4.963.15","unstructured":"Sharp GC . 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