{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:09:59Z","timestamp":1783048199284,"version":"3.54.6"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,2,15]]},"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Prematurity and its main respiratory complication, bronchopulmonary dysplasia (BPD), are potentially associated with lifelong respiratory morbidities and\/or lung function abnormalities. The mechanisms behind these long-term respiratory problems are still unclear.<\/jats:p><jats:p>We assessed airway oxidative stress in adolescents born very pre-term (\u226432 gestational weeks) by measuring 8-isoprostane concentration in exhaled breath condensate (EBC). In addition, the study protocol included spirometry and measurement of exhaled nitric oxide fraction (<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>).<\/jats:p><jats:p>The study groups included 34 ex-pre-term adolescents with BPD, 18 ex-pre-term adolescents without BPD and 34 healthy controls born at term.<\/jats:p><jats:p>Regardless of a history of BPD, the ex-premature adolescents had higher EBC 8-isoprostane levels (median (interquartile range) BPD 9.5 (7.3\u201312.2) pg\u00b7mL<jats:sup>\u22121<\/jats:sup>; pre-term non-BPD 10 (8.1\u201316) pg\u00b7mL<jats:sup>\u22121<\/jats:sup>) than the controls (3.2 (1.9\u20136.5) pg\u00b7mL<jats:sup>\u22121<\/jats:sup>) (p&lt;0.001). Forced expiratory volume in 1 s was lower in the BPD group (mean\u00b1<jats:sc>sd<\/jats:sc>Z-score -2.1\u00b11.58) than in the pre-term non-BPD individuals (-1.13\u00b11.15), who showed in turn significantly lower values than the controls (0.18\u00b10.83; p&lt;0.001).<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>was similar in the three groups (p=0.55).<\/jats:p><jats:p>Our data show that, after premature birth, evidence of oxidative stress in the airways may be detected into adolescence, suggesting that long-term respiratory abnormalities after pre-term birth may be associated with an ongoing airway disease and not just a stabilised structural lung damage.<\/jats:p>","DOI":"10.1183\/09031936.00185511","type":"journal-article","created":{"date-parts":[[2012,3,10]],"date-time":"2012-03-10T03:15:08Z","timestamp":1331349308000},"page":"1253-1259","source":"Crossref","is-referenced-by-count":108,"title":["Evidence of unexpected oxidative stress in airways of adolescents born very pre-term"],"prefix":"10.1183","volume":"40","author":[{"given":"Marco","family":"Filippone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gea","family":"Bonetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Corradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Chiara","family":"Frigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Baraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2012,3,9]]},"reference":[{"key":"2024102021034384000_40.5.1253.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904308"},{"key":"2024102021034384000_40.5.1253.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68615-7"},{"key":"2024102021034384000_40.5.1253.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2024102021034384000_40.5.1253.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra067279"},{"key":"2024102021034384000_40.5.1253.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200705-701OC"},{"key":"2024102021034384000_40.5.1253.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0046OC"},{"key":"2024102021034384000_40.5.1253.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2522"},{"key":"2024102021034384000_40.5.1253.8","doi-asserted-by":"publisher","DOI":"10.1080\/08035250410028101"},{"key":"2024102021034384000_40.5.1253.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012273232603"},{"key":"2024102021034384000_40.5.1253.10","doi-asserted-by":"publisher","DOI":"10.1080\/15412550701815965"},{"key":"2024102021034384000_40.5.1253.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0602ED"},{"key":"2024102021034384000_40.5.1253.12","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200905-027DS"},{"key":"2024102021034384000_40.5.1253.13","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2010.108"},{"key":"2024102021034384000_40.5.1253.14","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283423e51"},{"key":"2024102021034384000_40.5.1253.15","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a2c184"},{"key":"2024102021034384000_40.5.1253.16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0434"},{"key":"2024102021034384000_40.5.1253.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00116107"},{"key":"2024102021034384000_40.5.1253.18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-411-1_5"},{"key":"2024102021034384000_40.5.1253.19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00029705"},{"key":"2024102021034384000_40.5.1253.20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"2024102021034384000_40.5.1253.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-5-10"},{"key":"2024102021034384000_40.5.1253.22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1289\/ehp.8506","article-title":"The effect of inhaled chromium on different exhaled breath condensate biomarkers among chrome-plating workers","volume":"114","author":"Caglieri","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2024102021034384000_40.5.1253.23","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1183\/09031936.00074909","article-title":"EIA and GC\/MS analysis of 8-isoprostane in EBC of children with problematic asthma","volume":"5","author":"Carraro","year":"2010","journal-title":"Eur Respir J"},{"key":"2024102021034384000_40.5.1253.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.046"},{"key":"2024102021034384000_40.5.1253.25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024102021034384000_40.5.1253.26","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0323OC"},{"key":"2024102021034384000_40.5.1253.27","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00293102"},{"key":"2024102021034384000_40.5.1253.28","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00071110"},{"key":"2024102021034384000_40.5.1253.29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004635"},{"key":"2024102021034384000_40.5.1253.30","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200808-092RM"},{"key":"2024102021034384000_40.5.1253.31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052885"},{"key":"2024102021034384000_40.5.1253.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61379-8"},{"key":"2024102021034384000_40.5.1253.33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1419"},{"key":"2024102021034384000_40.5.1253.34","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0821"},{"key":"2024102021034384000_40.5.1253.35","doi-asserted-by":"publisher","DOI":"10.1177\/1753465807082373"},{"key":"2024102021034384000_40.5.1253.36","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2206011"},{"key":"2024102021034384000_40.5.1253.37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-298OC"},{"key":"2024102021034384000_40.5.1253.38","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"2024102021034384000_40.5.1253.39","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.10.832"},{"key":"2024102021034384000_40.5.1253.40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804752"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00185511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:35:49Z","timestamp":1740378949000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00185511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,9]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,10,31]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1183\/09031936.00185511"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00185511","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,9]]}}}