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Bronchoconstriction at high altitude could be excluded as the cause of changes in closing volume because there was no difference in airway resistance and bronchodilator responsiveness to salbutamol. There were no significant differences in these parameters between mountaineers with and without acute mountain sickness. Mild alveolar oedema on radiographs in HAPE was associated only with minor decreases in forced vital capacity, diffusing capacity and lung compliance and minor increases in closing volume.<\/jats:p><jats:p>Comprehensive lung function testing provided no evidence of interstitial pulmonary oedema in mountaineers without HAPE during the first 2\u2005days at 4,559\u2005m. Data obtained in mountaineers with early mild HAPE suggest that these methods may not be sensitive enough for the detection of interstitial pulmonary fluid accumulation.<\/jats:p>","DOI":"10.1183\/09031936.00185808","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T00:18:33Z","timestamp":1255997913000},"page":"812-820","source":"Crossref","is-referenced-by-count":64,"title":["No evidence for interstitial lung oedema by extensive pulmonary function testing at 4,559\u2005m"],"prefix":"10.1183","volume":"35","author":[{"given":"C.","family":"Dehnert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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