{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:27:28Z","timestamp":1789590448923,"version":"build-2803163510"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,7,4]]},"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>The association between bronchiolitis and recurrent wheezing remains controversial.<\/jats:p><jats:p>In this prospective study, we assessed risk factors for recurrent wheezing during a 12-month follow-up in 313 infants aged &lt;12 months hospitalised for their first episode of bronchiolitis. Demographic, clinical and laboratory data were obtained with a questionnaire and from medical files. A total of 14 respiratory viruses were concurrently assayed in nasal washings. Parents were interviewed 12 months after hospitalisation to check whether their infants experienced recurrent wheezing.<\/jats:p><jats:p>The rate of recurrent wheezing was higher in infants with bronchiolitis than in controls (52.7<jats:italic>versus<\/jats:italic>10.3%; p&lt;0.001). Multivariate analysis identified rhinovirus (RV) infection (OR 3.3, 95% CI 1.0\u201311.1) followed by a positive family history for asthma (OR 2.5, 95% CI 1.2\u20134.9) as major independent risk factors for recurrent wheezing.<\/jats:p><jats:p>In conclusion, the virus most likely to be associated with recurrent wheezing at 12 months after initial bronchiolitis is RV, a viral agent that could predict infants prone to the development of recurrent wheezing.<\/jats:p>","DOI":"10.1183\/09031936.00188210","type":"journal-article","created":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T02:33:23Z","timestamp":1313721203000},"page":"396-402","source":"Crossref","is-referenced-by-count":102,"title":["Rhinovirus bronchiolitis and recurrent wheezing: 1-year 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