{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:30:35Z","timestamp":1789579835345,"version":"build-2803163510"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,4,24]]},"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>The aim of this study was to develop and validate a new method: a classification and regression tree (CART) based on easily accessible measures to predict mortality in patients with stable chronic obstructive pulmonary disease (COPD).<\/jats:p>\n                  <jats:p>\n                    This was a prospective study of two independent prospective cohorts: a derivation cohort with 611 recruited patients and a validation cohort with 348 patients, all followed for 5 yrs. CART analysis was used to predict 5-yr mortality risk using the following covariates from the derivation cohort: age, % predicted forced expiratory volume in 1 s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ), dyspnoea, physical activity, general health and number of hospital admissions for COPD exacerbations in the previous 2 yrs.\n                  <\/jats:p>\n                  <jats:p>\n                    Age (\u226575 or &lt;75 yrs) provided the first branch of the COPD-CART. The highest mortality risk (0.74) was seen in patients &gt;75 yrs of age with higher levels of dyspnoea and FEV\n                    <jats:sub>1<\/jats:sub>\n                    &lt;50% pred. Patients with the lowest risk of 5-yr mortality (0.04) were &lt;55 yrs of age with FEV\n                    <jats:sub>1<\/jats:sub>\n                    &gt;35% pred and one or no recent hospitalisations for COPD exacerbations.\n                  <\/jats:p>\n                  <jats:p>A simple decision tree that uses variables commonly gathered by physicians can provide a quick assessment of the severity of the disease, as measured by the risk of 5-yr mortality.<\/jats:p>","DOI":"10.1183\/09031936.00189010","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T21:16:01Z","timestamp":1305234961000},"page":"1294-1300","source":"Crossref","is-referenced-by-count":53,"title":["Development of a decision tree to assess the severity and prognosis of stable COPD"],"prefix":"10.1183","volume":"38","author":[{"given":"C.","family":"Esteban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Arostegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Moraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aburto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"P\u00e9rez-Izquierdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aizpiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Capelastegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,5,12]]},"reference":[{"key":"2024102020395513000_38.6.1294.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021322"},{"key":"2024102020395513000_38.6.1294.2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl110"},{"key":"2024102020395513000_38.6.1294.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61301-5"},{"key":"2024102020395513000_38.6.1294.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.12.005"},{"key":"2024102020395513000_38.6.1294.5","doi-asserted-by":"crossref","unstructured":"Zhang H Singer B . 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