{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:21Z","timestamp":1791398301376,"version":"4.3.3"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,4,26]]},"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>The aim of the present study was to investigate to what extent interstitial lung disease (ILD) in common variable immunodeficiency disorder (CVID)-associated granulomatous disease (GD) is similar to pulmonary sarcoidosis<\/jats:p><jats:p>20 patients with CVID\/GD were included in a retrospective study conducted by the Groupe Sarco\u00efdose Francophone. Medical records were centralised. Patients were compared with 60 controls with sarcoidosis.<\/jats:p><jats:p>Clinical examination showed more frequent crackles in patients than controls (45%<jats:italic>versus<\/jats:italic>1.7%, respectively; p&lt;0.001). On thoracic computed tomography scans, nodules (often multiple and with smooth margins), air bronchograms and halo signs were more frequent in patients than controls (80%<jats:italic>versus<\/jats:italic>42%, respectively; p=0.004) as well as bronchiectasis (65%<jats:italic>versus<\/jats:italic>23%, respectively; p&lt;0.001). The micronodule distribution was perilymphatic in 100% of controls and in 42% of patients (p&lt;0.001). Bronchoalveolar lavage analysis showed lower T-cell CD4\/CD8 ratios in patients than in controls (mean\u00b1<jats:sc>sd<\/jats:sc>1.6\u00b11.1<jats:italic>versus<\/jats:italic>5.3\u00b14, respectively; p&lt;0.01). On pathological analysis, nodules and consolidations corresponded to granulomatous lesions with or without lymphocytic disorders in most cases. Mortality was higher in patients than controls (30%<jats:italic>versus<\/jats:italic>0%, respectively) and resulted from common variable immunodeficiency complications.<\/jats:p><jats:p>ILD in CVID\/GD presents a specific clinical picture and evolution that are markedly different from those of sarcoidosis.<\/jats:p>","DOI":"10.1183\/09031936.00189011","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T00:36:30Z","timestamp":1345250190000},"page":"115-122","source":"Crossref","is-referenced-by-count":90,"title":["Granulomatosis-associated common variable immunodeficiency disorder: a case\u2013control 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