{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:16:10Z","timestamp":1774120570392,"version":"3.50.1"},"reference-count":29,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,3,13]]},"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and to identify any effects of diagnosis and perinatal characteristics.<\/jats:p><jats:p>121 neonatal ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with other diagnoses) performed a total of 191 lung function measurements at 5, 8 and\/or 12 yrs. We assessed dynamic and static lung volumes, reversibility of airway obstruction and diffusion capacity.<\/jats:p><jats:p>Mean SDS forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) at 5 yrs before and after bronchodilation (-0.51 and 0.07) was significantly higher than at 8 (-0.79 and -0.4; p&lt;0.04) and 12 yrs (-1.10 and -0.52; p&lt;0.003). Mean SDS for all spirometric parameters before and after bronchodilation were significantly lower in the congenital diaphragmatic hernia group compared with the other diagnostic groups (all p\u22640.025). A significant volume of trapped air was observed in 86% patients with congenital diaphragmatic hernia, 50% with meconium aspiration syndrome and 58% with other diagnoses. After bronchodilation, mean SDS FEV<jats:sub>1<\/jats:sub>and forced vital capacity were negatively influenced by duration of ventilation (both p&lt;0.001) and duration of ECMO (p=0.003 and p=0.02, respectively).<\/jats:p><jats:p>Long-term pulmonary sequelae after neonatal ECMO-treatment mainly occur in congenital diaphragmatic hernia patients and tend to deteriorate over time.<\/jats:p>","DOI":"10.1183\/09031936.00189911","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T01:07:11Z","timestamp":1334106431000},"page":"1531-1537","source":"Crossref","is-referenced-by-count":26,"title":["Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation"],"prefix":"10.1183","volume":"40","author":[{"given":"Marjolein","family":"Spoel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxanne","family":"Laas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia J.","family":"Gischler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim J.C.","family":"Hop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke","family":"Ijsselstijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"2024102021064655000_40.6.1531.1","doi-asserted-by":"crossref","unstructured":"Mugford M Elbourne D Field D . 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