{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:34:33Z","timestamp":1774121673323,"version":"3.50.1"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,6,11]]},"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Cough is one of the commonest reasons for medical consultation and acute cough associated with upper respiratory tract infections (URTIs) is a global problem. In otherwise healthy volunteers complaining of cough associated with symptoms of URTI, we aimed to assess objective and subjective measures of cough and their repeatability and perform power calculations for the design of future studies to test therapies.<\/jats:p>\n                  <jats:p>We studied 54 otherwise healthy volunteers with acute cough (&lt;3 weeks) (median age 22 yrs (interquartile range 21\u201326 yrs), 64% female, mean forced expiratory volume in 1 s 97.6\u00b110.5% predicted). All subjects performed 24-h ambulatory cough monitoring and reported cough frequency and severity using visual analogue scales (VAS) on 2 consecutive days. Sample size calculations were performed for crossover and parallel group study designs.<\/jats:p>\n                  <jats:p>\n                    Objective cough frequency was high (session 1: geometric mean 12.1 coughs\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (95%CI 9.7\u201315.2)) and fell significantly (session 2: 9.0 coughs\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (95%CI 6.9\u201311.6); p&lt;0.001). Repeatability was higher for objective cough frequency (intra-class correlation coefficient (ICC)=0.94, p&lt;0.001) than reported cough frequency (daytime VAS ICC=0.784, p&lt;0.001). Crossover\/parallel studies require &lt;15 and &lt;41 subjects per arm to detect a 50% reduction in cough frequency with 90% power, respectively.\n                  <\/jats:p>\n                  <jats:p>Acute cough frequency is highly repeatable over any 48-h period, allowing small sample sizes to be used when investigating the effectiveness of novel anti-tussives.<\/jats:p>","DOI":"10.1183\/09031936.00190111","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:54:49Z","timestamp":1340844889000},"page":"277-284","source":"Crossref","is-referenced-by-count":24,"title":["Objective measurement of cough in otherwise healthy volunteers with acute cough"],"prefix":"10.1183","volume":"41","author":[{"given":"Kanchan","family":"Sunger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Powley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kelsall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Sumner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,6,27]]},"reference":[{"key":"2024102021121279000_41.2.277.1","first-page":"48","article-title":"Acute cough in adults","volume":"57","author":"Worrall","year":"2011","journal-title":"Can Fam Physician"},{"key":"2024102021121279000_41.2.277.2","first-page":"1","article-title":"National Ambulatory Medical Care Survey: 1991 summary.","volume":"13","author":"Schappert","year":"1994","journal-title":"Vital Health Stat"},{"key":"2024102021121279000_41.2.277.3","first-page":"1","article-title":"Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1999\u20132000.","volume":"13","author":"Burt","year":"2004","journal-title":"Vital Health Stat"},{"key":"2024102021121279000_41.2.277.4","unstructured":"National Ambulatory Medical Care Survey: 2009 summarytables. 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