{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:53:23Z","timestamp":1782708803675,"version":"3.54.5"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,4,24]]},"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Two, once daily (<jats:italic>q.d.<\/jats:italic>) inhaled bronchodilators are available for the treatment of chronic obstructive pulmonary disease (COPD): the \u03b2<jats:sub>2<\/jats:sub>-agonist indacaterol and the anticholinergic tiotropium. This blinded study compared the efficacy of these two agents and assessed their safety and tolerability.<\/jats:p><jats:p>Patients with moderate-to-severe COPD were randomised to treatment with indacaterol 150 \u03bcg<jats:italic>q.d.<\/jats:italic>(n=797) or tiotropium 18 \u03bcg<jats:italic>q.d.<\/jats:italic>(n=801) for 12 weeks.<\/jats:p><jats:p>After 12 weeks, the two treatments had similar overall effects on \u201ctrough\u201d (24 h post-dose) forced expiratory volume in 1 s. Indacaterol-treated patients had greater improvements in transition dyspnoea index (TDI) total score (least squares means 2.01<jats:italic>versus<\/jats:italic>1.43; p&lt;0.001) and St George\u2019s Respiratory Questionnaire (SGRQ) total score (least squares means 37.1<jats:italic>versus<\/jats:italic>39.2; p&lt;0.001; raw mean change from baseline -5.1<jats:italic>versus<\/jats:italic>-3.0), and were significantly more likely to achieve clinically relevant improvements in these end-points (indacaterol<jats:italic>versus<\/jats:italic>tiotropium odds ratios of 1.49 for TDI and 1.43 for SGRQ, both p&lt;0.001). Adverse events were recorded for 39.7% and 37.2% of patients in the indacaterol and tiotropium treatment groups, respectively. The most frequent adverse events were COPD worsening, cough and nasopharyngitis.<\/jats:p><jats:p>Both bronchodilators demonstrated spirometric efficacy. The two treatments were well tolerated with similar adverse event profiles. Compared with tiotropium, indacaterol provided significantly greater improvements in clinical outcomes.<\/jats:p>","DOI":"10.1183\/09031936.00191810","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T03:06:48Z","timestamp":1306465608000},"page":"797-803","source":"Crossref","is-referenced-by-count":99,"title":["Blinded 12-week comparison of once-daily indacaterol and tiotropium in COPD"],"prefix":"10.1183","volume":"38","author":[{"given":"R.","family":"Buhl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Disdier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Amos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Henley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,5,26]]},"reference":[{"key":"2024102020405970000_38.4.797.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 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