{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:02:27Z","timestamp":1792796547984,"version":"4.5.0"},"reference-count":92,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,2,8]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Acute respiratory distress syndrome (ARDS) continues to be a major healthcare problem, affecting &gt;190 000 people in the USA annually, with a mortality of 27\u201345%, depending on the severity of the illness and comorbidities. Despite advances in clinical care, particularly lung protective strategies of mechanical ventilation, most survivors experience impaired health-related quality of life for years after the acute illness. While most patients survive the acute illness, a subset of ARDS survivors develops a fibroproliferative response characterised by fibroblast accumulation and deposition of collagen and other extracellular matrix components in the lung.<\/jats:p><jats:p>Historically, the development of severe fibroproliferative lung disease has been associated with a poor prognosis with high mortality and\/or prolonged ventilator dependence. More recent studies also support a relationship between the magnitude of the fibroproliferative response and long-term health-related quality of life. The factors that determine which patients develop fibroproliferative ARDS and the cellular mechanisms responsible for this pathological response are not well understood.<\/jats:p><jats:p>This article reviews our current understanding of the contribution of pulmonary dysfunction to mortality and to quality of life in survivors of ARDS, the mechanisms driving pathological fibroproliferation and potential therapeutic approaches to prevent or attenuate fibroproliferative lung disease.<\/jats:p>","DOI":"10.1183\/09031936.00196412","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T03:18:01Z","timestamp":1363922281000},"page":"276-285","source":"Crossref","is-referenced-by-count":334,"title":["The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance"],"prefix":"10.1183","volume":"43","author":[{"given":"Ellen L.","family":"Burnham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.H.","family":"Riches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Downey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"2024102021372110000_43.1.276.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90168-7"},{"key":"2024102021372110000_43.1.276.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.137"},{"key":"2024102021372110000_43.1.276.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"2024102021372110000_43.1.276.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.6.646"},{"key":"2024102021372110000_43.1.276.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"2024102021372110000_43.1.276.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"2024102021372110000_43.1.276.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0503OC"},{"key":"2024102021372110000_43.1.276.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022450"},{"key":"2024102021372110000_43.1.276.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011802"},{"key":"2024102021372110000_43.1.276.10","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000168609.98847.50"},{"key":"2024102021372110000_43.1.276.11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2438"},{"key":"2024102021372110000_43.1.276.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200206-542OC"},{"key":"2024102021372110000_43.1.276.13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0685"},{"key":"2024102021372110000_43.1.276.14","unstructured":"Jones PW Forde Y . St George\u2019s Respiratory Questionnaire Manual. London, University of London, 2009. Available from: www.healthstatus.sgul.ac.uk\/sgrq\/sgrq-downloads ."},{"key":"2024102021372110000_43.1.276.15","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199401000-00004"},{"key":"2024102021372110000_43.1.276.16","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.1.r99ja2629"},{"key":"2024102021372110000_43.1.276.17","doi-asserted-by":"publisher","DOI":"10.1007\/s003300101103"},{"key":"2024102021372110000_43.1.276.18","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31826a5062"},{"key":"2024102021372110000_43.1.276.19","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822d7bf0"},{"key":"2024102021372110000_43.1.276.20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60331"},{"key":"2024102021372110000_43.1.276.21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130158"},{"key":"2024102021372110000_43.1.276.22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"2024102021372110000_43.1.276.23","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0348TR"},{"key":"2024102021372110000_43.1.276.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00032111"},{"key":"2024102021372110000_43.1.276.25","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2011"},{"key":"2024102021372110000_43.1.276.26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2103040"},{"key":"2024102021372110000_43.1.276.27","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0963-x"},{"key":"2024102021372110000_43.1.276.28","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9711112"},{"key":"2024102021372110000_43.1.276.29","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.3.652"},{"key":"2024102021372110000_43.1.276.30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115351"},{"key":"2024102021372110000_43.1.276.31","doi-asserted-by":"publisher","DOI":"10.1038\/nm1685"},{"key":"2024102021372110000_43.1.276.32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.637"},{"key":"2024102021372110000_43.1.276.33","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819fc81a"},{"key":"2024102021372110000_43.1.276.34","first-page":"1963","article-title":"Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality","volume":"149","author":"Yi","year":"1996","journal-title":"Am J Pathol"},{"key":"2024102021372110000_43.1.276.35","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9711111"},{"key":"2024102021372110000_43.1.276.36","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0092OC"},{"key":"2024102021372110000_43.1.276.37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110551"},{"key":"2024102021372110000_43.1.276.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117988108"},{"key":"2024102021372110000_43.1.276.39","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142225"},{"key":"2024102021372110000_43.1.276.40","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328344c3d4"},{"key":"2024102021372110000_43.1.276.41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420997"},{"key":"2024102021372110000_43.1.276.42","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0964-9"},{"key":"2024102021372110000_43.1.276.43","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200208000-00003"},{"key":"2024102021372110000_43.1.276.44","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2817-8"},{"key":"2024102021372110000_43.1.276.45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0272-5231(21)00143-X","article-title":"Structural alterations of lung parenchyma in the adult respiratory distress syndrome","volume":"3","author":"Bachofen","year":"1982","journal-title":"Clin Chest Med"},{"key":"2024102021372110000_43.1.276.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70158-1"},{"key":"2024102021372110000_43.1.276.47","first-page":"730","article-title":"Lung parenchyma remodeling in acute respiratory distress syndrome","volume":"75","author":"Rocco","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"2024102021372110000_43.1.276.48","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.4049\/jimmunol.162.9.5511","article-title":"Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis","volume":"162","author":"Keane","year":"1999","journal-title":"J Immunol"},{"key":"2024102021372110000_43.1.276.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.10.002"},{"key":"2024102021372110000_43.1.276.50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1224"},{"key":"2024102021372110000_43.1.276.51","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00074701"},{"key":"2024102021372110000_43.1.276.52","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2105057"},{"key":"2024102021372110000_43.1.276.53","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00065504"},{"key":"2024102021372110000_43.1.276.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030046"},{"key":"2024102021372110000_43.1.276.55","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-1-199501010-00003"},{"key":"2024102021372110000_43.1.276.56","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.5.1091"},{"key":"2024102021372110000_43.1.276.57","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9801107"},{"key":"2024102021372110000_43.1.276.58","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00298303"},{"key":"2024102021372110000_43.1.276.59","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.1.197"},{"key":"2024102021372110000_43.1.276.60","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000257325.88144.30"},{"key":"2024102021372110000_43.1.276.61","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2201012"},{"key":"2024102021372110000_43.1.276.62","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.2001061"},{"key":"2024102021372110000_43.1.276.63","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2503-2"},{"key":"2024102021372110000_43.1.276.64","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000257254.87984.69"},{"key":"2024102021372110000_43.1.276.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.10.001"},{"key":"2024102021372110000_43.1.276.66","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00074709"},{"key":"2024102021372110000_43.1.276.67","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822d718b"},{"key":"2024102021372110000_43.1.276.68","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.69"},{"key":"2024102021372110000_43.1.276.69","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-011-0740-3"},{"key":"2024102021372110000_43.1.276.70","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.556"},{"key":"2024102021372110000_43.1.276.71","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1534OC"},{"key":"2024102021372110000_43.1.276.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.01.012"},{"key":"2024102021372110000_43.1.276.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2011.04.001"},{"key":"2024102021372110000_43.1.276.74","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318207ec3c"},{"key":"2024102021372110000_43.1.276.75","first-page":"155","article-title":"Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis","volume":"26","author":"Barlo","year":"2009","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2024102021372110000_43.1.276.76","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052052"},{"key":"2024102021372110000_43.1.276.77","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106157"},{"key":"2024102021372110000_43.1.276.78","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373041515"},{"key":"2024102021372110000_43.1.276.79","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2011-000545","article-title":"Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study","volume":"2","author":"Ichikado","year":"2012","journal-title":"BMJ Open"},{"key":"2024102021372110000_43.1.276.80","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1979-0"},{"key":"2024102021372110000_43.1.276.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.12.085"},{"key":"2024102021372110000_43.1.276.82","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.2.159"},{"key":"2024102021372110000_43.1.276.83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051693"},{"key":"2024102021372110000_43.1.276.84","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2100"},{"key":"2024102021372110000_43.1.276.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.06.008"},{"key":"2024102021372110000_43.1.276.86","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003421"},{"key":"2024102021372110000_43.1.276.87","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3434"},{"key":"2024102021372110000_43.1.276.88","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2011.595714"},{"key":"2024102021372110000_43.1.276.89","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.327"},{"key":"2024102021372110000_43.1.276.90","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60551-1"},{"key":"2024102021372110000_43.1.276.91","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030511"},{"key":"2024102021372110000_43.1.276.92","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1874OC"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00196412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:43:18Z","timestamp":1740379398000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00196412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":92,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,12,31]]},"published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1183\/09031936.00196412"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00196412","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]}}}