{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T01:32:14Z","timestamp":1779327134315,"version":"3.51.4"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MICA grant G0901226"],"award-info":[{"award-number":["MICA grant G0901226"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2015,1,16]]},"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Idiopathic pulmonary fibrosis (IPF) and fibrotic nonspecific interstitial pneumonitis are progressive interstitial lung diseases (ILDs) with limited treatment options and poor survival. However, the rate of disease progression is variable, implying there may be different endotypes of disease. We hypothesised that immunophenotyping biopsies from ILD patients might reveal distinct endotypes of progressive fibrotic disease, which may facilitate stratification when undertaking clinical trials of novel therapies for IPF.<\/jats:p>\n                  <jats:p>43 paraffin-embedded, formalin-fixed lung tissue sections were immunostained for five molecules implicated in the pathogenesis of the fibrosis: \u03b1-smooth muscle actin (\u03b1SMA), \u03b1v\u03b26 integrin, pro-surfactant protein C (SP-C), hepatocyte growth factor (HGF) and tenascin-C (TenC). Levels of immunostaining and numbers of fibroblastic foci were quantified using operator-dependent and -independent methods. The relationship of all these markers to overall survival was analysed.<\/jats:p>\n                  <jats:p>Staining revealed high levels of \u03b1SMA, \u03b1v\u03b26 integrin, pro-SP-C, HGF and TenC, and fibroblastic foci. Immunostaining varied across samples for all molecules but only the extent of \u03b1v\u03b26 integrin immunostaining was associated with increased mortality. There was no association with the other markers measured.<\/jats:p>\n                  <jats:p>Our data suggest high levels of \u03b1v\u03b26 integrin may identify a specific endotype of progressive fibrotic lung disease.<\/jats:p>","DOI":"10.1183\/09031936.00210414","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T21:42:56Z","timestamp":1425591776000},"page":"486-494","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["\u03b1v\u03b26 integrin may be a potential prognostic biomarker in interstitial lung disease"],"prefix":"10.1183","volume":"46","author":[{"given":"Gauri","family":"Saini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Porte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul 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