{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:37:53Z","timestamp":1772627873129,"version":"3.50.1"},"reference-count":27,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,5,3]]},"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (<jats:italic>R<\/jats:italic><jats:sub>rs<\/jats:sub>) and compliance (<jats:italic>C<\/jats:italic><jats:sub>rs<\/jats:sub>) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort.<\/jats:p><jats:p>SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file.<\/jats:p><jats:p>549 infants had a successful SOT measurement and complete medical records. Every kPa\u00b7L<jats:sup>\u22121<\/jats:sup>\u00b7s<jats:sup>\u22121<\/jats:sup>increase in<jats:italic>R<\/jats:italic><jats:sub>rs<\/jats:sub>was associated with 10% more consultations in the first 3 years of life. Every 10 mL\u00b7kPa<jats:sup>\u22121<\/jats:sup>increase in<jats:italic>C<\/jats:italic><jats:sub>rs<\/jats:sub>was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with late-onset or persistent wheezing had significant lower<jats:italic>C<\/jats:italic><jats:sub>rs<\/jats:sub>values than their peers.<\/jats:p><jats:p>An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma.<\/jats:p>","DOI":"10.1183\/09031936.00214711","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T03:20:27Z","timestamp":1352431227000},"page":"107-115","source":"Crossref","is-referenced-by-count":21,"title":["Reduced neonatal lung function and wheezing illnesses during the first 5 years of life"],"prefix":"10.1183","volume":"42","author":[{"given":"Anne C.","family":"van der Gugten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuno S.P.M.","family":"Uiterwaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nienke","family":"van Putte-Katier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo J.M.","family":"Verheij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"2024102021245355000_42.1.107.1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1164\/ajrccm\/143.2.312","article-title":"Initial airway function is a risk factor for recurrent wheezing respiratory illnesses during the first three years of life. 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