{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:44:48Z","timestamp":1791423888911,"version":"4.3.3"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,2,16]]},"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>We tested the ability of exercise testing to predict not only survival, but also time to clinical worsening (TTCW) in idiopathic<jats:italic>versus<\/jats:italic>associated pulmonary arterial hypertension (PAH).<\/jats:p><jats:p>136 patients with PAH (85 idiopathic and 51 with associated conditions) underwent cardiopulmonary exercise testing and a 6-min walk test. Death or transplantation, and clinical worsening events were recorded.<\/jats:p><jats:p>32 patients died and four had lung transplantation. In a univariate analysis, PAH patients survival was associated with oxygen uptake (<jats:italic>V<\/jats:italic>\u2032<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>) at peak exercise and at the anaerobic threshold, ventilatory equivalent for carbon dioxide (minute ventilation (<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub><jats:italic>)<\/jats:italic>\/carbon dioxide production (<jats:italic>V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>) at the anaerobic threshold (<jats:sub>at<\/jats:sub>)),<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>\/<jats:italic>V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>slope and distance walked. TTCW was associated with peak<jats:italic>V<\/jats:italic>\u2032<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>and<jats:italic>V<\/jats:italic>\u2032<jats:sub>O<jats:sub>2<\/jats:sub>,at<\/jats:sub>,<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>\/<jats:italic>V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub>,at<\/jats:sub>, end-tidal carbon dioxide tension measured at the anaerobic threshold, peak oxygen pulse, increase in oxygen pulse and distance walked. In a multivariable analysis, distance walked and<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>\/<jats:italic>V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub>,at<\/jats:sub>predicted survival, and only peak<jats:italic>V<\/jats:italic>\u2032<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>predicted TTCW. The receiver operating characteristic curve-derived cut-off values were 305 m for the 6-min walk distance, 54 for<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>\/<jats:italic>V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub>,at<\/jats:sub>and 11.6 mL\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min for peak<jats:italic>V<\/jats:italic>\u2032<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>. In the subgroup with associated PAH, no variable independently predicted either survival or clinical worsening.<\/jats:p><jats:p>We conclude that several exercise variables predict survival and clinical stability in idiopathic PAH. Exercise variables are less accurate predictors of outcome in associated PAH.<\/jats:p>","DOI":"10.1183\/09031936.00217911","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T15:37:43Z","timestamp":1332517063000},"page":"1410-1419","source":"Crossref","is-referenced-by-count":109,"title":["Exercise testing to predict outcome in idiopathic<i>versus<\/i>associated pulmonary arterial hypertension"],"prefix":"10.1183","volume":"40","author":[{"given":"Ga\u00ebl","family":"Deboeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Scoditti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Huez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Vachi\u00e9ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lamotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Sharples","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Melot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Naeije","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"2024102021054568000_40.6.1410.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192230"},{"key":"2024102021054568000_40.6.1410.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139009"},{"key":"2024102021054568000_40.6.1410.3","doi-asserted-by":"publisher","DOI":"10.1161\/hc2901.093198"},{"key":"2024102021054568000_40.6.1410.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0351"},{"key":"2024102021054568000_40.6.1410.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9906015"},{"key":"2024102021054568000_40.6.1410.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02012-0"},{"key":"2024102021054568000_40.6.1410.7","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31817c92c0"},{"key":"2024102021054568000_40.6.1410.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.911818"},{"key":"2024102021054568000_40.6.1410.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057010"},{"key":"2024102021054568000_40.6.1410.10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.898122"},{"key":"2024102021054568000_40.6.1410.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.007"},{"key":"2024102021054568000_40.6.1410.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000022687.18568.2A"},{"key":"2024102021054568000_40.6.1410.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00104807"},{"key":"2024102021054568000_40.6.1410.14","unstructured":"Wasserman K Hansen JE Sue DY . 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