{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:42:46Z","timestamp":1778107366158,"version":"3.51.4"},"reference-count":18,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,3,5]]},"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The efficacy and safety of two doses of aclidinium bromide were evaluated in patients with moderate to severe chronic obstructive pulmonary disease (COPD).<\/jats:p><jats:p>In this 24-week, double-blind trial, patients were randomised to twice-daily aclidinium (200 \u03bcg or 400 \u03bcg) or placebo. The primary efficacy end-point was change in trough forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) at week 24. Other end-points included peak FEV<jats:sub>1<\/jats:sub>, health status (St George's Respiratory Questionnaire; SGRQ) and dyspnoea (Transitional Dyspnoea Index; TDI).<\/jats:p><jats:p>Overall, 828 patients were randomised. At week 24, significant improvements from baseline were observed with aclidinium 200 \u03bcg and 400 \u03bcg<jats:italic>versus<\/jats:italic>placebo for trough FEV<jats:sub>1<\/jats:sub>(99 and 128 mL; both p&lt;0.0001) and peak FEV<jats:sub>1<\/jats:sub>(185 and 209 mL; both p&lt;0.0001). Peak FEV<jats:sub>1<\/jats:sub>improvements on day 1 were comparable with week 24. Aclidinium 200 \u03bcg and 400 \u03bcg produced significant improvements over placebo in baseline-adjusted mean SGRQ total score (-3.8 and -4.6 units; p&lt;0.001 and p&lt;0.0001) and TDI focal score (0.6 and 1.0 units; p&lt;0.05 and p&lt;0.001) at week 24. With both aclidinium doses, the incidence of anticholinergic adverse events was low, and similar to placebo.<\/jats:p><jats:p>Twice-daily aclidinium significantly improved bronchodilation, health status and dyspnoea, and was well tolerated in patients with COPD.<\/jats:p>","DOI":"10.1183\/09031936.00225511","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T15:37:43Z","timestamp":1332517063000},"page":"830-836","source":"Crossref","is-referenced-by-count":135,"title":["Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN study"],"prefix":"10.1183","volume":"40","author":[{"given":"Paul W.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvar","family":"Agusti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Lamarca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"de Miquel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Segarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Caracta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Garcia Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"2024102021055416000_40.4.830.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61380-4"},{"key":"2024102021055416000_40.4.830.2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for Diagnosis, Management, and Prevention of COPD. www.goldcopd.com. Date last updated: 2010. Date last accessed: August 26, 2011."},{"key":"2024102021055416000_40.4.830.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105482"},{"key":"2024102021055416000_40.4.830.4","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-55"},{"key":"2024102021055416000_40.4.830.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00099306"},{"key":"2024102021055416000_40.4.830.6","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200053377"},{"key":"2024102021055416000_40.4.830.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0406"},{"key":"2024102021055416000_40.4.830.8","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2012.661492"},{"key":"2024102021055416000_40.4.830.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024102021055416000_40.4.830.10","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050513"},{"key":"2024102021055416000_40.4.830.11","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050666"},{"key":"2024102021055416000_40.4.830.12","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-40"},{"key":"2024102021055416000_40.4.830.13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.5414\/CPP47460","article-title":"Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subjects","volume":"47","author":"Jansat","year":"2009","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2024102021055416000_40.4.830.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.01.004"},{"key":"2024102021055416000_40.4.830.15","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.5.399"},{"key":"2024102021055416000_40.4.830.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00269802"},{"key":"2024102021055416000_40.4.830.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.47"},{"key":"2024102021055416000_40.4.830.18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00238702"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00225511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:36:23Z","timestamp":1740378983000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00225511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,22]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,9,30]]},"published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1183\/09031936.00225511"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00225511","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,22]]}}}