{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:05:40Z","timestamp":1790633140193,"version":"4.1.0"},"reference-count":55,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,5,31]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Chronic pulmonary aspergillosis (CPA) may complicate pulmonary sarcoidosis. We re-estimated the global burden of sarcoidosis and the burden of CPA complicating sarcoidosis.<\/jats:p><jats:p>We searched the literature and reference lists of retrieved papers to identify all published sarcoidosis incidence and prevalence data. We estimated the frequency of CPA from 11 papers relating to &gt;3,000 patients with sarcoidosis to derive CPA patient numbers. We applied an annual attrition rate of 15% (range 10\u201325%) to estimate the global burden of CPA.<\/jats:p><jats:p>We estimate that the annual incidence of sarcoidosis is 344,000 patients worldwide and the prevalence is \u223c1,238,000 cases, distributed as follows: 165,979 in Europe, 224,000 in the Americas, 492,892 in Africa, 80,023 in the Eastern Mediterranean, 41,660 in the West Pacific and 234,010 in Southeast Asia. CPA complicates sarcoidosis in 3\u201312% of cases. Using a 6% frequency, we estimate a global burden of 71,907 (range 35,954\u2013143,815 (3\u201312%)) CPA cases complicating sarcoidosis, with 24% and 37% of cases estimated to be present in the Americas and Africa, because of the higher incidence of sarcoidosis in black people.<\/jats:p><jats:p>As CPA responds to long-term antifungal therapy, which may prevent life-threatening haemoptysis, screening periodically for CPA in those with pulmonary sarcoidosis may be important, especially in patients requiring corticosteroid therapy.<\/jats:p>","DOI":"10.1183\/09031936.00226911","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T04:54:49Z","timestamp":1340859289000},"page":"621-626","source":"Crossref","is-referenced-by-count":165,"title":["Global burden of chronic pulmonary aspergillosis complicating sarcoidosis"],"prefix":"10.1183","volume":"41","author":[{"given":"David W.","family":"Denning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Pleuvry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2012,6,27]]},"reference":[{"key":"2024102021123710000_41.3.621.1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181775a73"},{"key":"2024102021123710000_41.3.621.2","unstructured":"Denning DW . 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