{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:05:04Z","timestamp":1790186704937,"version":"4.1.0"},"reference-count":53,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,3,15]]},"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>The modest daytime hypertension and sympathetic upregulation associated with the sleep apnoea\/hypopnoea syndrome (SAHS), does not explain the relatively large increased risk of cardiac morbidity and mortality in the SAHS patients population. Therefore, efferent vagal and sympathetic activity was evaluated during wakefulness in SAHS subjects and matched healthy controls, in order to determine if vagal downregulation may play a role in the aetiology of cardiac disease in the SAHS.<\/jats:p><jats:p>The awake autonomic nervous system function of 15 male subjects, with mild-to-moderate SAHS was compared to that of 14 healthy controls matched for age, body mass index, gender and blood pressure. All subjects were free from comorbidity. Vagal activity was estimated from measurements of heart rate variability high frequency power (HF) and sympathetic activity was measured from urine catecholamine excretion.<\/jats:p><jats:p>The %HF power was significantly (p&lt;0.03) reduced in SAHS patients (10\u00b11.6 (mean\u00b1sem)) as compared to controls (17\u00b13). In addition, HF power correlated with the apnoea\/hypopnoea index in the SAHS subjects (R=\u22120.592, p=0.02). There was no statistically significant difference in the daytime excretion of nonadrenaline between control (242\u00b130 nmol\u00b7collection<jats:sup>\u22121<\/jats:sup>) and SAHS (316\u00b146 nmol\u00b7collection<jats:sup>\u22121<\/jats:sup>) subjects (p=0.38).<\/jats:p><jats:p>In these sleep apnoea\/hypopnoea syndrome patients there was limited evidence of increased waking levels of urine catecholamines. The principal component altering waking autonomic nervous system function, in the sleep apnoea\/hypopnoea syndrome subjects, was a reduced daytime efferent vagal tone.<\/jats:p>","DOI":"10.1183\/09031936.01.00009301","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"1258-1266","source":"Crossref","is-referenced-by-count":51,"title":["The sleep apnoea\/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation"],"prefix":"10.1183","volume":"17","author":[{"given":"M.F.","family":"Hilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.A.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Cayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"2024101808475888000_17.6.1258.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.3.722"},{"key":"2024101808475888000_17.6.1258.2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00004872-198812040-00166","volume":"6","year":"1988","journal-title":"J Hypertens"},{"key":"2024101808475888000_17.6.1258.3","first-page":"413","volume":"10","year":"1988","journal-title":"Clin Exp Hypertens"},{"key":"2024101808475888000_17.6.1258.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1183"},{"key":"2024101808475888000_17.6.1258.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.6.1763"},{"key":"2024101808475888000_17.6.1258.6","doi-asserted-by":"crossref","unstructured":"Loredo JS, Ziegler MG, Ancoli-Israel S, Clausen JL, Dimsdale JE. 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