{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:40:01Z","timestamp":1740379201920,"version":"3.37.3"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,7,18]]},"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>The aim of this study was to investigate whether patients with laryngeal hemiplegia (LH) show a frequency-dependent increase in specific airway resistance (s<jats:italic>R<\/jats:italic><jats:sub>aw<\/jats:sub>), measured by body plethysmography.<\/jats:p><jats:p>In addition to the flow-volume loop, usually considered in the functional evaluation of upper airway obstructions, variations in s<jats:italic>R<\/jats:italic><jats:sub>aw<\/jats:sub>at respiratory frequencies of 30\u00b15 (=0.5\u2005Hz), 60\u00b15 (=1\u2005Hz) and 90\u00b15\u2005breaths\u00b7min<jats:sup>\u22121<\/jats:sup>(=1.5\u2005Hz) in 21 never-smoking patients (LH group, mean age\u00b1sd 55\u00b112.09\u2005yrs; 17 females) whose unilateral vocal-cord paralysis was documented by laryngoscopy and who had no signs or symptoms of other respiratory diseases studied. They were compared to 21 healthy control subjects (C group: 50.1\u00b115.44\u2005yrs; 10 females).<\/jats:p><jats:p>The s<jats:italic>R<\/jats:italic><jats:sub>aw<\/jats:sub>values at 30\u00b15\u2005breaths\u00b7min<jats:sup>\u22121<\/jats:sup>were similar in the two groups (5.54\u00b11.88<jats:italic>versus<\/jats:italic>5.68\u00b11.06\u2005cmH<jats:sub>2<\/jats:sub>O\u00b7s<jats:sup>\u22121<\/jats:sup>; p=ns), but at increasing frequencies (30\u00b15, 60\u00b15 and 90\u00b15\u2005breaths\u00b7min<jats:sup>\u22121<\/jats:sup>), they progressively and significantly increased in the LH patients (from 5.54\u00b11.88 to 6.63\u00b11.96 and 8.05\u00b12.6\u2005cmH<jats:sub>2<\/jats:sub>O\u00b7s<jats:sup>\u22121<\/jats:sup>; p&lt;0.0005), and not significantly in controls (5.68\u00b11.06, 5.85\u00b10.95 and 5.9\u00b11.12\u2005cmH<jats:sub>2<\/jats:sub>O\u00b7s; p=ns). Linear discriminant analysis using \u0394s<jats:italic>R<\/jats:italic><jats:sub>aw<\/jats:sub>(s<jats:italic>R<\/jats:italic><jats:sub>aw<\/jats:sub>at 1.5\u2005Hz-s<jats:italic>R<\/jats:italic><jats:sub>aw<\/jats:sub>at 0.5\u2005Hz) and forced inspiratory flow at 50% of the vital capacity made it possible to correctly classify all of the controls and 19 of the 21 patients.<\/jats:p><jats:p>In conclusion, the multiple, rapid and noninvasive plethysmographical testing of frequency-dependent increase in specific airway resistance with the flow-volume loop, allows the sufficiently satisfactory discrimination of laryngeal hemiplegia patients from controls.<\/jats:p>","DOI":"10.1183\/09031936.01.00061501","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:36:48Z","timestamp":1027773408000},"page":"1003-1008","source":"Crossref","is-referenced-by-count":8,"title":["Increased frequency dependence of specific airway resistance in patients with laryngeal hemiplegia"],"prefix":"10.1183","volume":"18","author":[{"given":"V.","family":"Fasano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Raiteri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bucchioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cantarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Massari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Cesana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Allegra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2024101808591069000_18.6.1003.1","first-page":"325","volume":"40","year":"1979","journal-title":"ORL"},{"key":"2024101808591069000_18.6.1003.2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1288\/00005537-198407000-00013","volume":"94","year":"1984","journal-title":"Laryngoscope"},{"key":"2024101808591069000_18.6.1003.3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1152\/jappl.1968.24.3.296","volume":"24","year":"1968","journal-title":"J Appl Physiol"},{"key":"2024101808591069000_18.6.1003.4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/jappl.1964.19.4.653","volume":"19","year":"1964","journal-title":"J Appl Physiol"},{"key":"2024101808591069000_18.6.1003.5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1152\/jappl.1971.31.5.708","volume":"31","year":"1971","journal-title":"J Appl Physiol"},{"key":"2024101808591069000_18.6.1003.6","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJM196806202782501","volume":"278","year":"1968","journal-title":"N Engl J Med"},{"key":"2024101808591069000_18.6.1003.7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1172\/JCI105999","volume":"48","year":"1969","journal-title":"J Clin Invest"},{"key":"2024101808591069000_18.6.1003.8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1172\/JCI103282","volume":"35","year":"1956","journal-title":"J Clin Invest"},{"key":"2024101808591069000_18.6.1003.9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1152\/jappl.1972.32.4.460","volume":"32","year":"1972","journal-title":"J Appl Physiol"},{"key":"2024101808591069000_18.6.1003.10","first-page":"474","volume":"59","year":"1966","journal-title":"Acta-oto-laryng"},{"key":"2024101808591069000_18.6.1003.11","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"2024101808591069000_18.6.1003.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.63.2.171"},{"key":"2024101808591069000_18.6.1003.13","unstructured":"Lachenbruch PA. 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