{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:56:12Z","timestamp":1791014172359,"version":"4.1.0"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,3,10]]},"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>The European Epidemiologic Registry of Cystic Fibrosis began collecting longitudinal data on European cystic fibrosis patients in 1994. A cross-sectional analysis was performed to identify the factors associated with low values of % predicted forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) upon patient enrolment.<\/jats:p><jats:p>Data from 7,010 patients aged \u22656\u2005yrs were included. Clinical conditions, microbiological isolates and medications reported at enrolment or within the following 180 days were analysed for age-specific associations.<\/jats:p><jats:p>Factors associated with FEV<jats:sub>1<\/jats:sub>that were lower by &gt;10% of pred values were: lower weight for age percentiles, haemoptysis, pneumothorax, pulmonary symptoms at presentation,<jats:italic>Pseudomonas aeruginosa<\/jats:italic>,<jats:italic>Burkholderia cepacia<\/jats:italic>, oral corticosteroids, nonsteroid anti-inflammatory drugs, dornase alfa, oxygen and assisted ventilation and, in patients &gt;12\u2005yrs old only, use of airway clearance techniques, inhaled bronchodilators, oral nutritional supplements, pancreatic enzymes and insulin or oral hypoglycaemics. Slightly impaired lung function (5\u201310%) was associated with: diabetes (\u226518-yrs-old), gastro-oesophageal reflux, allergic bronchopulmonary aspergillosis, asthma-like symptoms, portal hypertension,<jats:italic>Aspergillus<\/jats:italic>spp. and<jats:italic>Candida<\/jats:italic>spp. Sex,<jats:italic>Haemophilus influenzae<\/jats:italic>and<jats:italic>Staphylococcus aureus<\/jats:italic>were not associated with impaired pulmonary status. Regular exercise (especially in older patients) and nasal polyposis were associated with slightly better FEV<jats:sub>1<\/jats:sub>.<\/jats:p><jats:p>The results confirm those of previous studies and suggest selective prescribing in sicker patients.<\/jats:p>","DOI":"10.1183\/09031936.01.00068901","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:36:48Z","timestamp":1027773408000},"page":"298-305","source":"Crossref","is-referenced-by-count":146,"title":["Factors associated with poor pulmonary function: cross-sectional analysis of data from the ERCF"],"prefix":"10.1183","volume":"18","author":[{"given":"J.","family":"Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rainisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.K.","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Hodson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mastella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Strandvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"2024101808522810000_18.2.298.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83478-X"},{"key":"2024101808522810000_18.2.298.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5058.774"},{"key":"2024101808522810000_18.2.298.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.003141"},{"key":"2024101808522810000_18.2.298.4","unstructured":"FitzSimmons SC. 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