{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:44:55Z","timestamp":1783734295088,"version":"3.55.0"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,5,7]]},"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>This study aimed to investigate the effect of increased lung volume with positive end-expiratory pressure (PEEP) on respiratory resistance in patients with chronic obstructive pulmonary disease (COPD).<\/jats:p><jats:p>Ten patients with COPD were mechanically ventilated for acute respiratory failure. PEEP was set at 0, 5, 10 and 15 cmH<jats:sub>2<\/jats:sub>O. Using the rapid airway occlusion technique, the total inspiratory resistance of the respiratory system was partitioned into interrupter (<jats:italic>R<\/jats:italic><jats:sub>int,rs<\/jats:sub>) and additional effective (\u0394<jats:italic>R<\/jats:italic><jats:sub>rs<\/jats:sub>) resistances. At each level of PEEP, at constant inflation flow, the inflation volume (\u0394<jats:italic>V<\/jats:italic>) was varied from 0.2\u20131 L, and, at constant \u0394<jats:italic>V<\/jats:italic>, the inflation flow was varied from 0.2\u20131.2 L\u00b7s<jats:sup>\u22121<\/jats:sup>. The changes in end-expiratory lung volume (\u0394EELV) induced by PEEP were also measured.<\/jats:p><jats:p>The difference between the EELV and the relaxation volume of the respiratory system (\u0394FRC) increased significantly with PEEP of 10 and 15 cmH<jats:sub>2<\/jats:sub>O as compared to a PEEP of 0, the increase being associated with a significant reduction of<jats:italic>R<\/jats:italic><jats:sub>int,rs<\/jats:sub>. By contrast, \u0394<jats:italic>R<\/jats:italic><jats:sub>rs<\/jats:sub>was independent of \u0394FRC. At constant \u0394<jats:italic>V<\/jats:italic>,<jats:italic>R<\/jats:italic><jats:sub>int,rs<\/jats:sub>fitted Rohrer's equation (<jats:italic>R<\/jats:italic><jats:sub>int,rs<\/jats:sub>=K<jats:sub>1<\/jats:sub>+K<jats:sub>2<\/jats:sub>\u00d7flow). While K<jats:sub>2<\/jats:sub>significantly declined with \u0394FRC, K<jats:sub>1<\/jats:sub>did not change. At all levels of PEEP, \u0394<jats:italic>R<\/jats:italic><jats:sub>rs<\/jats:sub>was not influenced by \u0394FRC.<\/jats:p><jats:p>With increasing lung volume induced by positive end-expiratory pressure, the inspiratory airway resistance decreased, whereas the viscoelastic behaviour of the respiratory system, as reflected by additional effective resistance, did not change.<\/jats:p>","DOI":"10.1183\/09031936.01.00072001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:36:43Z","timestamp":1027773403000},"page":"491-498","source":"Crossref","is-referenced-by-count":18,"title":["Effects of PEEP on inspiratory resistance in mechanically ventilated COPD 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