{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:01:33Z","timestamp":1778842893914,"version":"3.51.4"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,1,19]]},"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>Episodic wheezing associated with viral infections of the upper respiratory tract (URT) is a common problem in young children but also occurs in adults. It is hypothesized that an experimental infection with human coronavirus (HCoV), the second most prevalent common cold virus, would cause lower respiratory tract (LRT) changes in adults with a history of viral wheeze.<\/jats:p><jats:p>Twenty-four viral wheezers (15 atopic) and 19 controls (seven atopic) were inoculated with HCoV 229E and monitored for the development of symptoms, changes in airway physiology and provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) (PC<jats:sub>20<\/jats:sub>). At baseline, viral wheezers were similar to controls in PC<jats:sub>20<\/jats:sub>(mean\u00b1sd log<jats:sub>2<\/jats:sub>PC<jats:sub>20<\/jats:sub>: 5.1\u00b11.9 and 5.8\u00b11.4\u2005g\u00b7L<jats:sup>\u22121<\/jats:sup>, respectively) but had a lower FEV<jats:sub>1<\/jats:sub>than controls (mean\u00b1sd 85.8\u00b111.4 and 95.6\u00b113.2% predicted, respectively p&lt;0.05). Nineteen viral wheezers and 11 controls developed colds. Viral wheezers with colds reported significantly more URT symptoms than controls (median scores (interquartile range): 24 (10\u201337) and 6 (4\u201315), respectively p=0.014). Sixteen viral wheezers and no controls reported LRT symptoms (wheeze, chest tightness and shortness of breath). The viral wheezers with colds had small (3\u20134%) reductions in FEV<jats:sub>1<\/jats:sub>and peak expiratory flow on days with LRT symptoms (days 3\u20136), but a progressive reduction in PC<jats:sub>20<\/jats:sub>from baseline on days 2, 4 and 17 after inoculation (by 0.82, 1.35 and 1.82 doubling concentrations, respectively). The fall in PC<jats:sub>20<\/jats:sub>affected both atopic and nonatopic subjects equally. There were no changes in FEV<jats:sub>1<\/jats:sub>or PC<jats:sub>20<\/jats:sub>in controls.<\/jats:p><jats:p>An adult model of viral wheeze that is independent of atopy and therefore, of classical atopic asthma was established.<\/jats:p>","DOI":"10.1183\/09031936.01.00073101","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"23-32","source":"Crossref","is-referenced-by-count":19,"title":["A model of viral wheeze in nonasthmatic adults: symptoms and physiology"],"prefix":"10.1183","volume":"18","author":[{"given":"M.C.","family":"Mckean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.C.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Myint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2024101808503680000_18.1.23.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.12.1200"},{"key":"2024101808503680000_18.1.23.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"2024101808503680000_18.1.23.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111567"},{"key":"2024101808503680000_18.1.23.4","doi-asserted-by":"crossref","unstructured":"Mckean MC, Ducharme F. Inhaled steroids for episodic viral wheeze in children. Cochrane Library, 1999.","DOI":"10.1002\/14651858.CD001107"},{"key":"2024101808503680000_18.1.23.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01254.x"},{"key":"2024101808503680000_18.1.23.6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113843"},{"key":"2024101808503680000_18.1.23.7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.5.7582282"},{"key":"2024101808503680000_18.1.23.8","first-page":"S879","volume":"151","year":"1995","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2024101808503680000_18.1.23.9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.6.9196088"},{"key":"2024101808503680000_18.1.23.10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9610079"},{"key":"2024101808503680000_18.1.23.11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.7.500"},{"key":"2024101808503680000_18.1.23.12","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.5.502"},{"key":"2024101808503680000_18.1.23.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6910.982"},{"key":"2024101808503680000_18.1.23.14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6989.1225"},{"key":"2024101808503680000_18.1.23.15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"2024101808503680000_18.1.23.16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1958.00260140099015"},{"key":"2024101808503680000_18.1.23.17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/jmv.1890290113","volume":"29","year":"1989","journal-title":"J Med Virol"},{"key":"2024101808503680000_18.1.23.18","first-page":"256","volume":"39","year":"1992","journal-title":"Prog Med Virol"},{"key":"2024101808503680000_18.1.23.19","first-page":"S53","volume":"6","year":"1993","journal-title":"Eur Respir J"},{"key":"2024101808503680000_18.1.23.20","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.1994.1052"},{"key":"2024101808503680000_18.1.23.21","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(90)90159-E"},{"key":"2024101808503680000_18.1.23.22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1128\/jcm.12.4.493-497.1980","volume":"12","year":"1980","journal-title":"J Clin Microbiol"},{"key":"2024101808503680000_18.1.23.23","first-page":"587","volume":"113","year":"1976","journal-title":"Am Rev Respir Dis"},{"key":"2024101808503680000_18.1.23.24","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3109\/00016489309135878","volume":"113","year":"1993","journal-title":"Acta Otolaryngol"},{"key":"2024101808503680000_18.1.23.25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1017\/S0950268800048019","volume":"105","year":"1990","journal-title":"Epidem Inf"},{"key":"2024101808503680000_18.1.23.26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5568.767"},{"key":"2024101808503680000_18.1.23.27","unstructured":"Schellenberg RR. Mechanisms of airway hyperresponsiveness In: Page CP, Gardiner PJ, editors. Airway Hyperresponsiveness: Is It Really Important For Asthma? Oxford, Blackwell Scientific, 1999; pp. 33\u2013\u201355."},{"key":"2024101808503680000_18.1.23.28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2222.1996.tb00593.x","volume":"26","year":"1996","journal-title":"Clin Exper Allergy"},{"key":"2024101808503680000_18.1.23.29","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9707163"},{"key":"2024101808503680000_18.1.23.30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00010.x"},{"key":"2024101808503680000_18.1.23.31","first-page":"1108","volume":"8","year":"1998","journal-title":"Eur Respir Rev"},{"key":"2024101808503680000_18.1.23.32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9712082"},{"key":"2024101808503680000_18.1.23.33","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.157.4.1605","volume":"157","year":"1996","journal-title":"J Immunol"},{"key":"2024101808503680000_18.1.23.34","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9117003"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.01.00073101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:37:15Z","timestamp":1740382635000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.01.00073101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]},"published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1183\/09031936.01.00073101"],"URL":"https:\/\/doi.org\/10.1183\/09031936.01.00073101","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}