{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:53:45Z","timestamp":1761486825339,"version":"3.37.3"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,4,4]]},"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>The aim was to study the tuberculin skin test in relation to immunological<jats:italic>in vitro<\/jats:italic>reactions in bacille Calmette-Gu\u00e9rin (BCG)-vaccinated healthcare workers.<\/jats:p><jats:p>The present study was performed in Sweden, a country with a low incidence of tuberculosis, a high BCG vaccination efficacy and high tuberculin conversion rates. BCG-vaccinated healthcare workers (n=381) were tuberculin skin tested. From these, 11 subjects with negative tuberculin reactions (&lt;6\u2005mm) were matched for age and sex with 11 subjects with large positive reactions (\u226515\u2005mm). Lymphocyte transformation and the production of interferon-gamma (IFN-\u03b3) were analysed after stimulation<jats:italic>in vitro<\/jats:italic>of peripheral blood mononuclear cells with tuberculin purified protein derivative, heat-killed tubercle bacilli and a culture filtrate from tubercle bacilli.<\/jats:p><jats:p>In the tuberculin-positive group the lymphocyte transformation response was 2\u20133 times larger, and IFN-\u03b3 production was 7\u201310 times larger, than in the tuberculin-negative group (p&lt;0.001).<\/jats:p><jats:p>The present results suggest that a positive tuberculin skin test in bacille Calmette-Gu\u00e9rin-vaccinated subjects indicates a stronger immune response of the protective T-helper 1-type than does a negative test. In similar settings, the study supports the traditional practice of regarding the tuberculin skin test in bacille Calmette-Gu\u00e9rin-vaccinated subjects as an indicator of a protective immune response against tuberculosis.<\/jats:p>","DOI":"10.1183\/09031936.01.00086901","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:37:15Z","timestamp":1027773435000},"page":"376-380","source":"Crossref","is-referenced-by-count":7,"title":["The tuberculin skin test in relation to immunological<i>in vitro<\/i>reactions in BCG-vaccinated healthcare workers"],"prefix":"10.1183","volume":"18","author":[{"given":"H.","family":"Fj\u00e4llbrant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ridell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.O.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"2024101808532354000_18.2.376.1","first-page":"234","volume":"15","year":"1947","journal-title":"Am Rev Tuberc"},{"key":"2024101808532354000_18.2.376.2","unstructured":"Rosenthal SR. 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