{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:20:37Z","timestamp":1791897637621,"version":"4.3.4"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,6,10]]},"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p>Hypersensitivity to beryllium (Be) is found in 1\u201316% of exposed workers undergoing immunological screening for beryllium disease using the beryllium lymphocyte proliferation test (BeLPT). However, only \u223c50% of BeLPT-positive workers present with lung granulomas (<jats:italic>i.e.<\/jats:italic>berylliosis). As berylliosis is associated with the human leukocyte antigen (HLA)-DP supratypic marker DPGlu69, the authors asked whether this marker is differentially associated with disease presentation.<\/jats:p><jats:p>A population of 639 workers from a beryllium factory undergoing BeLPT screening was evaluated in a nested case-control study for the prevalence of HLA-DPGlu69, the HLA-DPB1, HLA-DQ and HLA-DR alleles and of the biallelic tumour necrosis factor (TNF)-;\u03b1 polymorphism TNF-;\u03b1-;308 in 23 individuals presenting as \u201csensitized\u201d (<jats:italic>i.e.<\/jats:italic>BeLPT-positive without lung granulomas) and in 22 presenting as \u201cdiseased\u201d (<jats:italic>i.e.<\/jats:italic>BeLPT-positive with granulomas in the lung biopsy).<\/jats:p><jats:p>The HLA-DPGlu69 marker was associated with \u201cdisease\u201d (odds ratio (OR) 3.7, p=0.016, 95% confidence interval (CI) 1.4\u201310.0), whilst the high TNF-;\u03b1 production-related TNF-;\u03b1-;308*2 marker was associated with both a positive BeLPT (OR 7.8, corrected p&lt;0.0001, 95% CI 3.2\u201319.1) with no difference between \u201csensitization\u201d and \u201cdisease\u201d. Furthermore, the HLA-DRArg74 marker was associated with \u201csensitization\u201d without disease (OR 3.96, p=0.005, 95% CI 1.5\u201310.1).<\/jats:p><jats:p>The data indicate that tumour necrosis factor-;\u03b1, human leukocyte antigen-DR and human leukocyte antigen-DP markers play different roles in beryllium sensitization and granuloma formation in beryllium-exposed workers.<\/jats:p>","DOI":"10.1183\/09031936.01.00106201","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:36:48Z","timestamp":1027773408000},"page":"677-684","source":"Crossref","is-referenced-by-count":76,"title":["Major histocompatibility locus genetic markers of beryllium sensitization and 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