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Molecular biology strategies have recently allowed the identification of the K<jats:sup>+<\/jats:sup>channel subunits expressed in these specialized cells.<\/jats:p><jats:p>Several voltage-gated K<jats:sup>+<\/jats:sup>channel subunits comprising six transmembrane segments and a single pore domain (Kv1.2, Kv1.5, Kv2.1, Kv3.1, Kv3.3, Kv4.2 and Kv9.3) are reversibly blocked by hypoxia when expressed in heterologous expression systems. Additionally, the background K<jats:sup>+<\/jats:sup>channel subunit TASK-1, which comprises four transmembrane segments and two pore domains, is also involved in both oxygen- and acid-sensing in peripheral chemoreceptors.<\/jats:p><jats:p>Progress is currently being made to identify the oxygen sensors. Regulatory \u03b2 subunits may play an important role in the modulation of Kv channel subunits by oxygen.<\/jats:p>","DOI":"10.1183\/09031936.01.00204001","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"221-227","source":"Crossref","is-referenced-by-count":133,"title":["Molecular physiology of oxygen-sensitive potassium 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