{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:05:08Z","timestamp":1791057908431,"version":"4.1.0"},"reference-count":15,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2000,10,18]]},"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Viscous negatively charged cystic fibrosis (CF) sputum allows colonization by pathogens, inducing a chronic inflammatory response. Heparin thins sputum by decreasing the mucin molecule amino group negative charge, altering its intermolecular hydrogen bonding, and ionically shielding its polyionic moieties. It also has an anti-inflammatory effect within the lung. It may, therefore, be useful in the treatment of CF patients.<\/jats:p><jats:p>In order to test this, six fully informed<jats:italic>Burkholderia cepacia<\/jats:italic>colonized stable adult CF patients, received 25,000\u2005IU nebulized heparin sulphate daily for 7 days. Subjective sputum parameters, spirometry, platelets, coagulation parameters, and serum and sputum interleukin (IL)\u20106 and \u20108 were measured before and after treatment.<\/jats:p><jats:p>All patients tolerated the heparin with no evidence of bleeding, thrombocytopenia or change in coagulation parameters. There was no change in spirometry, but a reduction in interleukins (sputum IL\u20106, p=0.01; sputum IL\u20108, p=0.002; serum IL\u20106, p=0.02; serum IL\u20108, p=0.02). Sputum was easier to expectorate (p&lt;0.04), with a trend towards thinner sputum (p=0.07) but no change in sputum volume.<\/jats:p><jats:p>Heparin therapy was well tolerated and had an anti-inflammatory effect, with subjective sputum mucolysis. Further studies are necessary to define the role of heparin in the treatment of cystic fibrosis patients.<\/jats:p>","DOI":"10.1183\/09031936.01.17100360","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:36:48Z","timestamp":1027773408000},"page":"36-38","source":"Crossref","is-referenced-by-count":29,"title":["Nebulized heparin in<i>Burkholderia cepacia<\/i>colonized adult cystic fibrosis patients"],"prefix":"10.1183","volume":"17","author":[{"given":"M.","family":"Ledson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Walshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"2024101808340215000_17.1.36.1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.60.3.539-574.1996"},{"key":"2024101808340215000_17.1.36.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520783"},{"key":"2024101808340215000_17.1.36.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1995.tb00095.x"},{"key":"2024101808340215000_17.1.36.4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199605)21:5<267::AID-PPUL1>3.3.CO;2-G"},{"key":"2024101808340215000_17.1.36.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60471-8"},{"key":"2024101808340215000_17.1.36.6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.6.8665036"},{"key":"2024101808340215000_17.1.36.7","unstructured":"Geddes DM. Future prospects. In:: Hodson ME, Geddes DM, editors. Cystic Fibrosis. London, UK, Chapman and Hall, 1995; 422\u2013423."},{"key":"2024101808340215000_17.1.36.8","unstructured":"Lee MM, King M. Effect of low molecular weight heparin on the elasticity of dog mucus. Proc 22nd European Cystic Fibrosis Conference, Berlin, Germany, 1998;: 144."},{"key":"2024101808340215000_17.1.36.9","first-page":"17","volume":"12","year":"1992","journal-title":"Crit Rev Immunol"},{"key":"2024101808340215000_17.1.36.10","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1182\/blood.V82.11.3253.3253","volume":"82","year":"1993","journal-title":"Blood"},{"key":"2024101808340215000_17.1.36.11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-0038-1661157","volume":"52","year":"1984","journal-title":"Thrombos Haemostas"},{"key":"2024101808340215000_17.1.36.12","first-page":"14","volume":"73","year":"1996","journal-title":"Br Heart J"},{"key":"2024101808340215000_17.1.36.13","doi-asserted-by":"publisher","DOI":"10.1021\/bi00150a023"},{"key":"2024101808340215000_17.1.36.14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0037-1614206","volume":"79","year":"1998","journal-title":"Thrombos Haemostas"},{"key":"2024101808340215000_17.1.36.15","first-page":"298","volume":"4","year":"1978","journal-title":"Sem Thromb Hemost"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.01.17100360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:35:23Z","timestamp":1740382523000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.01.17100360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,1,1]]},"published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1183\/09031936.01.17100360"],"URL":"https:\/\/doi.org\/10.1183\/09031936.01.17100360","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,1]]}}}