{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:55:29Z","timestamp":1773773729391,"version":"3.50.1"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2000,12,18]]},"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>Sulphur dioxide (SO<jats:sub>2<\/jats:sub>) is an important air pollutant and causes bronchoconstriction in normal and asthmatic adults. This paper has explored the autonomic consequences of SO<jats:sub>2<\/jats:sub>exposure using the spectral analysis of heart rate variability.<\/jats:p><jats:p>Electrocardiogram recordings were made in 12 normal and 12 asthmatic adults undergoing pollutant exposures. Exposures were of a 1 h duration, double blind, in random order, \u22652 weeks apart and included air and 200 parts per billion SO<jats:sub>2<\/jats:sub>. Spectral analysis of R-R intervals was performed.<\/jats:p><jats:p>SO<jats:sub>2<\/jats:sub>exposure was associated with an increase in total power (TP) and high (HF) and low frequency (LF) power in the normal subjects, and a reduction in these indices in the subjects with asthma. The difference in TP with SO<jats:sub>2<\/jats:sub>exposure compared to air was +1730\u2009ms<jats:sup>2<\/jats:sup>in the normal group and \u22121021\u2009ms<jats:sup>2<\/jats:sup>asthmatic group (p&lt;0.003). For HF the respective values were +964\u2009ms<jats:sup>2<\/jats:sup>and \u2212539\u2009ms<jats:sup>2<\/jats:sup>(p=0.02) and for LF, +43 7\u2009ms<jats:sup>2<\/jats:sup>and \u221257 2\u2009ms<jats:sup>2<\/jats:sup>(p=0.01). No change in lung function or symptoms was observed in either group.<\/jats:p><jats:p>This suggests that SO<jats:sub>2<\/jats:sub>exposure at concentrations which are frequently encountered during air pollution episodes can influence the autonomic nervous system. This may be important in understanding the mechanisms involved in SO<jats:sub>2<\/jats:sub>induced bronchoconstriction, and of the cardiovascular effects of air pollution.<\/jats:p>","DOI":"10.1183\/09031936.01.17406040","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"604-608","source":"Crossref","is-referenced-by-count":92,"title":["The effect of sulphur dioxide exposure on indices of heart rate variability in normal and asthmatic adults"],"prefix":"10.1183","volume":"17","author":[{"given":"W.S.","family":"Tunnicliffe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Hilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Ayres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2024101808402063000_17.4.604.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10051064"},{"key":"2024101808402063000_17.4.604.2","unstructured":"Committee on the Medical Effects of Air PollutantsHandbook on air pollution and health London: HM Stationary office, 1997."},{"key":"2024101808402063000_17.4.604.3","unstructured":"Advisory Group on Medical Aspects of Air Pollution EpisodesSecond Report: Sulphur dioxide, acid aerosols and particulates. 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