{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:36:34Z","timestamp":1790861794079,"version":"4.1.0"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2000,10,26]]},"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>There are no reliable predictors of mortality in primary pulmonary hypertension (PPH). This study assessed whether exercise oxygen desaturation and distance achieved during a six-minute walk are associated with mortality in moderately symptomatic patients with PPH.<\/jats:p><jats:p>Thirty-four patients with PPH underwent a pretreatment six-minute walk test, and an invasive haemodynamic assessment of pulmonary vasodilator reserve, to select the best treatment option (epoprostenol in 27 and nifedipine in 7). Median follow-up was 26 months (12 months for the nonsurvivors was 26%), and median survival, &gt;46 months by Kaplan-Maier estimate.<\/jats:p><jats:p>The mean\u00b1sd distance walked was 275\u00b1155 m and reduction in arterial oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>a,O<\/jats:sub><jats:sub>2<\/jats:sub>) at maximal distance (\u0394<jats:italic>S<\/jats:italic><jats:sub>a,O<\/jats:sub><jats:sub>2<\/jats:sub>) was 8.4\u00b14.5%. A distance \u2264300 m increased mortality risk by 2.4, and a \u0394<jats:italic>S<\/jats:italic><jats:sub>a,O<\/jats:sub><jats:sub>2<\/jats:sub>of \u226510 % increased mortality risk by 2.9. Only<jats:italic>S<\/jats:italic><jats:sub>a,O<\/jats:sub><jats:sub>2<\/jats:sub>at peak distance, \u0394<jats:italic>S<\/jats:italic><jats:sub>a,O<\/jats:sub><jats:sub>2<\/jats:sub>and pulmonary vascular resistance (PVR) were related to mortality. After adjusting for PVR, there remained a 27% increase in risk of death for each per cent decrease in<jats:italic>S<\/jats:italic><jats:sub>a,O<\/jats:sub><jats:sub>2<\/jats:sub>.<\/jats:p><jats:p>The six-minute walk distance and exercise oxygen saturation may be helpful in selecting patients with primary pulmonary hypertension for whom transplant listing is appropriate.<\/jats:p>","DOI":"10.1183\/09031936.01.17406470","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"647-652","source":"Crossref","is-referenced-by-count":200,"title":["Oxygen desaturation on the six-minute walk test and mortality in untreated primary pulmonary hypertension"],"prefix":"10.1183","volume":"17","author":[{"given":"G.","family":"Paciocco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bossone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pielsticker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rubenfire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2024101808405236000_17.4.647.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"2024101808405236000_17.4.647.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360207"},{"key":"2024101808405236000_17.4.647.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-7-485"},{"key":"2024101808405236000_17.4.647.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-6-199409150-00003"},{"key":"2024101808405236000_17.4.647.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207093270203"},{"key":"2024101808405236000_17.4.647.6","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(85)90035-9"},{"key":"2024101808405236000_17.4.647.7","first-page":"919","volume":"132","year":"1985","journal-title":"Can Med Assoc J."},{"key":"2024101808405236000_17.4.647.8","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-199607000-00007"},{"key":"2024101808405236000_17.4.647.9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1055\/s-2007-1009415","volume":"19","year":"1998","journal-title":"Semin Resp and Crit Care Med"},{"key":"2024101808405236000_17.4.647.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.2.325"},{"key":"2024101808405236000_17.4.647.11","first-page":"451","volume":"4","year":"1992","journal-title":"Thorax"},{"key":"2024101808405236000_17.4.647.12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"2024101808405236000_17.4.647.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00361-1"},{"key":"2024101808405236000_17.4.647.14","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/0735-1097(92)90295-X","volume":"19","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2024101808405236000_17.4.647.15","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0735-1097(91)90556-O","volume":"18","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"2024101808405236000_17.4.647.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407073310107"},{"key":"2024101808405236000_17.4.647.17","doi-asserted-by":"publisher","DOI":"10.1136\/thx.39.11.818"},{"key":"2024101808405236000_17.4.647.18","unstructured":"Foss C. Pulse Oximetry with Exercise: Assessment of Desaturation, Oxygen Titration and Distance Walked. In: Wanger J, ed. Pulmonary Function and Laboratory Management and Procedural Manual: American Thoracic Society; 1998."},{"key":"2024101808405236000_17.4.647.19","first-page":"313","volume":"16","year":"1997","journal-title":"J Heart Lung Transplant"},{"key":"2024101808405236000_17.4.647.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9906015"},{"key":"2024101808405236000_17.4.647.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340504"},{"key":"2024101808405236000_17.4.647.22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1733"},{"key":"2024101808405236000_17.4.647.23","first-page":"276","volume":"13","year":"1994","journal-title":"J Heart Lung Transplant"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.01.17406470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:36:40Z","timestamp":1740382600000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.01.17406470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,4,1]]},"published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1183\/09031936.01.17406470"],"URL":"https:\/\/doi.org\/10.1183\/09031936.01.17406470","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}