{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:59:34Z","timestamp":1785445174804,"version":"3.56.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,1,17]]},"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>This study investigated the effects of \u03b2<jats:sub>2<\/jats:sub>-adrenergic agonist therapy on heart rate variability (HRV) in adult asthmatic patients by using frequency domain measures of HRV.<\/jats:p><jats:p>A randomized crossover design was used. Twenty adult patients with asthma were studied. All patients showed a mild-to-moderate decrease in baseline forced expiratory volume in one second. Any diseases that might have influenced the autonomic function were excluded. All patients had a complete physical examination and medical history that revealed no cardiovascular disease or medication. The study used 200\u2005\u00b5g inhaled salbutamol and 500\u2005\u00b5g inhaled terbutaline. HRV analysis was performed for each 5-min segment, 5\u2005min before inhalation of the study drug and 5, 10, 15, 20, 25 and 30\u2005min after inhalation. Total power (TP: &lt;0.40\u2005Hz), high-frequency power (HF: 0.15\u20130.40\u2005Hz), low-frequency power (LF: 0.04\u20130.15\u2005Hz) and LF\/HF ratio were calculated.<\/jats:p><jats:p>The LF and LF\/HF ratio increased and TP decreased at 5, 10, 15 and 20\u2005min after the salbutamol and the terbutaline inhalation, HF did not change significantly after the salbutamol and terbutaline inhalation.<\/jats:p><jats:p>Acute salbutamol and terbutaline inhalation produce similar effects on heart rate variability and increase sympathetic modulation in the cardiac autonomic activity.<\/jats:p>","DOI":"10.1183\/09031936.01.17508630","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"863-867","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic 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