{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:02:19Z","timestamp":1790942539557,"version":"4.1.0"},"reference-count":16,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2000,12,12]]},"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>The natural history of the development of sensitization and disease due to high-molecular-weight allergens is not well characterized. This study describes the time-course of the incidence of work-related symptoms, skin reactivity and occupational rhinoconjunctivitis (RC) and asthma (OA); and assesses the predictive value of skin testing and RC symptoms in apprentices exposed to laboratory animals, in a 3\u20134-yr programme.<\/jats:p><jats:p>Four-hundred and seventeen apprentices at five institutions were assessed prospectively with questionnaire, skin-testing with animal-derived allergens, spirometry and airway responsiveness (n=373). Depending on the school, students were seen 8 (n=136), 20 (n=345), 32 (n=355) and 44 (n=98) months after starting the programme.<\/jats:p><jats:p>At all visits, the incidence was greater for work-related RC symptoms followed in order by skin reactivity, occupational RC, and, almost equally, OA and work-related respiratory symptoms. The incidence-density figures were comparable for each follow-up period and for most indices up to 32 months after entry into the study and then tended to decrease. The positive predictive values (PPVs) of skin reactivity to work-related allergens for the development of work-related RC and respiratory symptoms were 30% and 9.0%, respectively, while the PPVs of work-related RC for the development of OA was 11.4%.<\/jats:p><jats:p>Sensitization, symptoms and diseases occur maximally in the first 2\u20133\u2005yrs after starting exposure to laboratory animals. Skin reactivity to work-related allergens and rhinoconjuctivitis symptoms have low positive predictive values.<\/jats:p>","DOI":"10.1183\/09031936.01.17509040","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"904-908","source":"Crossref","is-referenced-by-count":109,"title":["Natural history of sensitization, symptoms and occupational diseases in apprentices exposed to laboratory animals"],"prefix":"10.1183","volume":"17","author":[{"given":"D.","family":"Gautrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ghezzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Infante-Rivard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L.","family":"Malo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"2024101808443052000_17.5.904.1","unstructured":"Gordon S, Newman Taylor AJ. Animal, insect, and shellfish allergy In: Bernstein IL, Chan-Yeung M, Malo J-L, Bernstein DI, editors. 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Occupational asthma In: Hirsch A, Goldberg M, Martin JP, Masse M, editors. Prevention of respiratory diseases. Lung biology in health and disease series. Vol 68New York, Marcel Dekker Inc., 1993; pp. 117\u2013131.","DOI":"10.1201\/9781003573869-7"},{"key":"2024101808443052000_17.5.904.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10071513"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.01.17509040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:13:44Z","timestamp":1740377624000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.01.17509040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2001,5,1]]},"published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1183\/09031936.01.17509040"],"URL":"https:\/\/doi.org\/10.1183\/09031936.01.17509040","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}