{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:50:16Z","timestamp":1793728216165,"version":"4.6.1"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,7,2]]},"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>Medroxyprogesterone acetate (MPA) and acetazolamide (ACET) are two ventilatory stimulants which are used in hypoxic and hypercapnic patients with chronic obstructive pulmonary disease (COPD).<\/jats:p><jats:p>In a double-blind randomised study, the effects of a 2-week treatment with MPA (30\u2005mg<jats:italic>b.i.d.<\/jats:italic>) or ACET (250\u2005mg<jats:italic>b.i.d.<\/jats:italic>), followed by a 2-week treatment with a combination of both drugs (MPA\/ACET), on daytime and nocturnal ventilatory and blood gas parameters in 17 stable hypercapnic COPD patients were investigated.<\/jats:p><jats:p>ACET, MPA and MPA\/ACET treatment decreased mean daytime carbon dioxide tension in arterial blood by 0.4, 0.7 and 1.2\u2005kPa, respectively. Minute ventilation was improved only with combined therapy, from 9.3 to 11.2\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>.<\/jats:p><jats:p>With MPA\/ACET therapy, the hypercapnic and hypoxic ventilatory responses significantly increased, from 3.7 to 5.8\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7kPa<jats:sup>\u22121<\/jats:sup>and from \u22120.13 to \u22120.40\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7%<jats:sup>\u22121<\/jats:sup>, respectively. The mouth exclusion pressure response to hypoxia increased during combination therapy, from \u22120.01 to \u22120.03\u2005kPa\u00b7%<jats:sup>\u22121<\/jats:sup>. Nocturnal end-tidal carbon dioxide tension decreased with MPA and MPA\/ACET treatment, by 0.9 and 1.4\u2005kPa, respectively. MPA\/ACET significantly increased mean nocturnal arterial oxygen saturation values, from 85.5 to 90.2%.<\/jats:p><jats:p>The authors conclude that short-term combined treatment with medroxyprogesterone acetate and acetazolamide has a more favourable effect on day and night-time blood gas values and chemical drive than single drug treatment.<\/jats:p>","DOI":"10.1183\/09031936.02.00016402","type":"journal-article","created":{"date-parts":[[2002,11,8]],"date-time":"2002-11-08T00:31:11Z","timestamp":1036715471000},"page":"1130-1137","source":"Crossref","is-referenced-by-count":20,"title":["Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients"],"prefix":"10.1183","volume":"20","author":[{"given":"M.","family":"Wagenaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Je 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