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A serum biomarker that predicts clinical outcome would be useful to stage disease, indicate prognosis and the need for aggressive therapy, and help stratify patients for clinical trials.<\/jats:p><jats:p>The goals of this study were to determine whether serum levels of surfactant protein\u2010A (SP\u2010A) or surfactant protein\u2010D (SP\u2010D) would distinguish between IPF and other types of interstitial lung disease and whether serum SP\u2010A or SP\u2010D levels predict outcome in patients with IPF.<\/jats:p><jats:p>The authors found that serum SP\u2010A and SP\u2010D levels were significantly elevated in patients with IPF and systemic sclerosis compared to sarcoidosis, beryllium disease and normal controls, and that SP\u2010D correlated with radiographic abnormalities in patients with IPF. In addition, the authors found that both serum SP\u2010A and SP\u2010D levels were highly predictive of survival in patients with IPF.<\/jats:p><jats:p>This is the largest North American data set of surfactant protein measurements in idiopathic pulmonary fibrosis and the first report using multivariate analysis comparing serum surfactant proteins\u2010A and \u2010D to other commonly measured predictors of survival in idiopathic pulmonary fibrosis. Based on these results, the authors propose that serum surfactant proteins may prove to be useful biomarkers in patients with idiopathic pulmonary fibrosis.<\/jats:p>","DOI":"10.1183\/09031936.02.00081102","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:37:15Z","timestamp":1027773435000},"page":"439-446","source":"Crossref","is-referenced-by-count":269,"title":["Serum surfactant proteins\u2010A and \u2010D as biomarkers in idiopathic pulmonary fibrosis"],"prefix":"10.1183","volume":"19","author":[{"given":"K.E.","family":"Greene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"T.E.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kuroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bucher-Bartelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.W.","family":"Hunninghake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"2024101809072442000_19.3.439.1","unstructured":"Schwarz MI. 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