{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:49:57Z","timestamp":1762296597684,"version":"3.37.3"},"reference-count":14,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,8,2]]},"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>Symptoms of hypersensitivity pneumonitis and massive pulmonary haemorrhage occurred in a 24-yr-old male shortly after occupational exposure to naphthylene-1,5-diisocyanate (NDI).<\/jats:p><jats:p>The present examination was performed \u223c1-yr after the initial life-threatening haemoptysis and following an uneventful recovery after resection of the middle lobe, which had been identified bronchoscopically as the bleeding source. Histological re-examination of the lung was compatible with hypersensitivity pneumonitis.<\/jats:p><jats:p>After a chamber challenge with NDI (5 parts per billion (ppb) for 10\u2005min, 10\u2005ppb for 110\u2005min), rales were heard in both lungs, and a fall in vital capacity and partial pressure of arterial oxygen as well as a rise in body temperature were documented. Isocyanate-specific immunoglobulin-G antibodies could not be detected in the patient's serum, possibly due to the long period without exposure to isocyanates.<\/jats:p><jats:p>The authors conclude that naphthylene-1,5-diisocyanate may cause immunological pulmonary haemorrhage. The underlying disease is consistent with hypersensitivity pneumonitis and may be triggered by low concentrations of the diisocyanate.<\/jats:p>","DOI":"10.1183\/09031936.02.00244702","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:36:48Z","timestamp":1027773408000},"page":"377-380","source":"Crossref","is-referenced-by-count":19,"title":["Haemorrhagic hypersensitivity pneumonitis due to naphthylene-1,5-diisocyanate"],"prefix":"10.1183","volume":"19","author":[{"given":"R.","family":"Merget","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Marczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Remberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Raulf-Heimsoth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.O.","family":"Willroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Baur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,2,1]]},"reference":[{"key":"2024101809062768000_19.2.377.1","first-page":"328","volume":"2","year":"1979","journal-title":"Lancet"},{"key":"2024101809062768000_19.2.377.2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90085-8"},{"key":"2024101809062768000_19.2.377.3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000232838","volume":"66","year":"1981","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"2024101809062768000_19.2.377.4","first-page":"59","volume":"9","year":"1987","journal-title":"J Allergy Clin Immunol"},{"key":"2024101809062768000_19.2.377.5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1164\/ajrccm\/141.1.226","volume":"141","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"2024101809062768000_19.2.377.6","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"2024101809062768000_19.2.377.7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199802)33:2<114::AID-AJIM3>3.0.CO;2-Y"},{"key":"2024101809062768000_19.2.377.8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000237325","volume":"110","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"2024101809062768000_19.2.377.9","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90158-4"},{"key":"2024101809062768000_19.2.377.10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/00039896.1995.9935964","volume":"50","year":"1995","journal-title":"Arch Environ Health"},{"key":"2024101809062768000_19.2.377.11","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.6.762"},{"key":"2024101809062768000_19.2.377.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.4.563"},{"key":"2024101809062768000_19.2.377.13","unstructured":"Cartier A, Malo JL. Occupational challenge tests In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, editors. Asthma in the WorkplaceNew York, Marcel Dekker Inc, 1999; pp. 211\u2013234."},{"key":"2024101809062768000_19.2.377.14","first-page":"403","volume":"7","year":"1992","journal-title":"Occup Med"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.02.00244702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:13:51Z","timestamp":1740377631000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.02.00244702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,2,1]]},"published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1183\/09031936.02.00244702"],"URL":"https:\/\/doi.org\/10.1183\/09031936.02.00244702","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"type":"print","value":"0903-1936"},{"type":"electronic","value":"1399-3003"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}