{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T01:29:22Z","timestamp":1770427762494,"version":"3.49.0"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,4,11]]},"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>The aim of the present study was to examine the relationships between the responses to progressive isocapnic hypoxia and hypoxic withdrawal test in patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to analyse the determinants of carotid body sensitivity in OSAHS.<\/jats:p><jats:p>Nineteen consecutive OSAHS patients and 13 healthy subjects were selected. Ventilatory (\u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>\/BSA) and inspiratory neural drive (\u0394<jats:italic>P<\/jats:italic><jats:sub>0.1<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>) responses to progressive isocapnic hypoxia were determined. Peripheral chemosensitivity was evaluated by the hypoxic withdrawal test, which measures the decrease in ventilation caused by two breaths of 100% oxygen (%\u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>).<\/jats:p><jats:p>Withdrawal response and ventilatory and inspiratory neural drive responses to hypoxia were lower in OSAHS patients than in control subjects. In patients with OSAHS, %\u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>correlated significantly with \u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>\/BSA and with \u0394<jats:italic>P<\/jats:italic><jats:sub>0.1<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>. On stepwise multiple linear regression analysis, a strong correlation between %\u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>and \u0394<jats:italic>P<\/jats:italic><jats:sub>0.1<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>was found. Moreover, %\u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>, \u0394<jats:italic>V<\/jats:italic>\u2032<jats:sub>I<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>\/BSA and \u0394<jats:italic>P<\/jats:italic><jats:sub>0.1<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>were significantly correlated with minimum arterial oxygen saturation and with arousal index.<\/jats:p><jats:p>Obstructive sleep apnoea-hypopnoea syndrome patients have a strong relationship between peripheral chemosensitivity and respiratory response to hypoxia, suggesting that hypoxic stimulation of central chemoreceptors is minimally relevant in obstructive sleep apnoea-hypopnoea syndrome. Moreover, sensitivity of the carotid body in patients with obstructive sleep apnoea-hypopnoea syndrome is related to sleep disruption and to nocturnal hypoxia.<\/jats:p>","DOI":"10.1183\/09031936.02.00250102","type":"journal-article","created":{"date-parts":[[2002,9,6]],"date-time":"2002-09-06T21:12:37Z","timestamp":1031346757000},"page":"724-732","source":"Crossref","is-referenced-by-count":26,"title":["Inspiratory neural drive response to hypoxia adequately estimates peripheral chemosensitivity in OSAHS patients"],"prefix":"10.1183","volume":"20","author":[{"given":"F.","family":"Garc\u00eda-R\u00edo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Pino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Alvaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Villasante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"2024101809455577000_20.3.724.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1183"},{"key":"2024101809455577000_20.3.724.2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1183\/09031936.98.11010007","volume":"11","year":"1998","journal-title":"Eur Respir J"},{"key":"2024101809455577000_20.3.724.3","first-page":"359","volume":"12","year":"1995","journal-title":"Rev Mal Respir"},{"key":"2024101809455577000_20.3.724.4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/08037059409101521","volume":"3","year":"1994","journal-title":"Blood Press"},{"key":"2024101809455577000_20.3.724.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.5.1325"},{"key":"2024101809455577000_20.3.724.6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1164\/ajrccm\/145.4_Pt_1.837","volume":"145","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2024101809455577000_20.3.724.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13241899"},{"key":"2024101809455577000_20.3.724.8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0272-5231(21)00623-7","volume":"10","year":"1989","journal-title":"Clin Chest Med"},{"key":"2024101809455577000_20.3.724.9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.5.1417"},{"key":"2024101809455577000_20.3.724.10","first-page":"309","volume":"45","year":"1991","journal-title":"Pneumologie"},{"key":"2024101809455577000_20.3.724.11","first-page":"274","volume":"96","year":"1997","journal-title":"Circulation"},{"key":"2024101809455577000_20.3.724.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.6.1278"},{"key":"2024101809455577000_20.3.724.13","first-page":"986","volume":"126","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"2024101809455577000_20.3.724.14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/jappl.1982.52.3.537","volume":"52","year":"1982","journal-title":"J Appl Physiol"},{"key":"2024101809455577000_20.3.724.15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1152\/jappl.1983.54.4.874","volume":"54","year":"1983","journal-title":"J Appl Physiol"},{"key":"2024101809455577000_20.3.724.16","first-page":"109","volume":"50","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"2024101809455577000_20.3.724.17","first-page":"345","volume":"109","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"2024101809455577000_20.3.724.18","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(74)90015-2"},{"key":"2024101809455577000_20.3.724.19","unstructured":"Rechtschaffen A, Kales A. 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