{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:27:59Z","timestamp":1770910079692,"version":"3.50.1"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,1,16]]},"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>Gastro-oesophageal reflux is a common clinical disorder associated with a variety of respiratory symptoms, including chronic cough and exacerbation of asthma. In this study, the potential role of acid-induced tachykinin release was examined in guinea pigs and rabbits, by examining the effects of the tachykinin NK<jats:sub>1<\/jats:sub>and NK<jats:sub>3<\/jats:sub>receptors antagonists (SR 140333 and SR 142801, respectively) (1\u201310\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) on plasma protein extravasation induced in airways by hydrochloric acid (HCl) infusion in the oesophagus.<\/jats:p><jats:p>Guinea pigs were anaesthetised with urethane, while rabbits were subject to neuroleptoanalgesia with hypnorm. Airway vascular leakage was evaluated by measuring extravasation of Evans blue dye. All animals were pretreated with atropine (1\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup><jats:italic>i.p.<\/jats:italic>), propranolol (1\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup><jats:italic>i.p.<\/jats:italic>), phosphoramidon (2.5\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup><jats:italic>i.v.<\/jats:italic>) and saline or tachykinin receptor antagonists (1\u201310\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup><jats:italic>i.p.<\/jats:italic>).<\/jats:p><jats:p>Infusion of 1 N HCl into the oesophagus led to a three- and five-fold increase in plasma extravasation in the main bronchi and trachea, respectively. This increase was largely prevented by the tachykinin NK<jats:sub>1<\/jats:sub>and NK<jats:sub>3<\/jats:sub>receptor antagonists SR 140333 and SR 142801 (1\u201310\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><jats:p>These results suggest that protein extravasation in the airways, as induced by intra-oesophageal HCl infusion, is mainly dependent on the release of tachykinins, and that both NK<jats:sub>1<\/jats:sub>and NK<jats:sub>3<\/jats:sub>tachykinin receptors are involved. The results suggest that HCl-induced sensory nerve stimulation may act in the periphery on intermediate neurons and\/or ganglia where NK<jats:sub>3<\/jats:sub>receptors have been shown to play an important role.<\/jats:p>","DOI":"10.1183\/09031936.02.00250902","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T23:21:54Z","timestamp":1033514514000},"page":"268-273","source":"Crossref","is-referenced-by-count":31,"title":["Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation"],"prefix":"10.1183","volume":"20","author":[{"given":"S.","family":"Daoui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"D'Agostino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gallelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Emonds Alt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Advenier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2024101809384450000_20.2.268.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.7.479"},{"key":"2024101809384450000_20.2.268.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.5.1294"},{"key":"2024101809384450000_20.2.268.3","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90176-2"},{"key":"2024101809384450000_20.2.268.4","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1164\/arrd.1986.134.5.986","volume":"134","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"2024101809384450000_20.2.268.5","first-page":"431","volume":"47","year":"1981","journal-title":"Ann Allergy"},{"key":"2024101809384450000_20.2.268.6","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/0016-5085(84)90082-9","volume":"87","year":"1984","journal-title":"Gastroenterology"},{"key":"2024101809384450000_20.2.268.7","doi-asserted-by":"publisher","DOI":"10.1063\/1.370875"},{"key":"2024101809384450000_20.2.268.8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.68.1.29","volume":"68","year":"1981","journal-title":"Pediatrics"},{"key":"2024101809384450000_20.2.268.9","first-page":"306","volume":"42","year":"1979","journal-title":"Ann Allergy"},{"key":"2024101809384450000_20.2.268.10","first-page":"224","volume":"41","year":"1978","journal-title":"Ann Allergy"},{"key":"2024101809384450000_20.2.268.11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1475-097X.1981.tb00897.x","volume":"1","year":"1981","journal-title":"Clin Physiol"},{"key":"2024101809384450000_20.2.268.12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1152\/jappl.1997.82.3.738","volume":"82","year":"1997","journal-title":"J Appl Physiol"},{"key":"2024101809384450000_20.2.268.13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1474-8673.1993.tb00396.x","volume":"13","year":"1993","journal-title":"J Auton Pharmacol"},{"key":"2024101809384450000_20.2.268.14","doi-asserted-by":"publisher","DOI":"10.1006\/pulp.1994.1024"},{"key":"2024101809384450000_20.2.268.15","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08071193"},{"key":"2024101809384450000_20.2.268.16","first-page":"551","volume":"46","year":"1994","journal-title":"Pharmacol Rev"},{"key":"2024101809384450000_20.2.268.17","doi-asserted-by":"crossref","unstructured":"Baluk P, McDonald DM. 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