{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:25:08Z","timestamp":1773685508774,"version":"3.50.1"},"reference-count":8,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,10,1]]},"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>A prospective study was conducted to identify and characterize hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with serological evidence of infection with<jats:italic>Legionella<\/jats:italic>spp. (Lsp).<\/jats:p><jats:p>Two-hundred and forty hospital admissions for AECOPD of 213 patients were included in the study. Paired sera were obtained for each of the admissions and were tested for 41 different serogroups of Lsp, using microimmunofluorescence-serology. Only a significant change in immunoglobulin\u2010G and\/or immunoglobulin\u2010M antibody titres was considered diagnostic.<\/jats:p><jats:p>In 40 admissions (16.7%) there was serological evidence of infection with Lsp (LspH).<jats:italic>Legionella pneumophila<\/jats:italic>1 was identified in nine admissions,<jats:italic>L. pneumophila<\/jats:italic>3\u201315 in 19 and nonpneumophila in 22. In 26 LspH (65%) there was serological evidence of infection with at least one other respiratory pathogen. Compared to the 200 admissions without Lsp (NLspH), the LspH patients were younger (p&lt;0.05) and more hypoxaemic (p&lt;0.04). None of the cases in the LspH group had an abrupt onset of disease, compared to 58 (29.0%) in the NLspH group (p&lt;0.0001). The incidence of myalgia\/arthralgia was 55% for LspH compared to 37% for NLspH (p&lt;0.03).<\/jats:p><jats:p>To conclude, serological evidence of infection with<jats:italic>Legionella<\/jats:italic>spp. is common among patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease. In most hospital admissions with serological evidence of infection with<jats:italic>Legionella<\/jats:italic>spp. an additional respiratory pathogen can be identified. Acute exacerbation develops gradually in these patients and is characterized clinically by more systemic manifestations than hospital admissions without serological evidence of infection with<jats:italic>Legionella<\/jats:italic>spp. The true interpretation and practical relevance of these findings should be determined in further studies.<\/jats:p>","DOI":"10.1183\/09031936.02.00256702","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:37:15Z","timestamp":1027773435000},"page":"392-397","source":"Crossref","is-referenced-by-count":38,"title":["Serological evidence of<i>Legionella<\/i>species infection in acute exacerbation of COPD"],"prefix":"10.1183","volume":"19","author":[{"given":"D.","family":"Lieberman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Shmarkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Gelfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ben-Yaakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Lazarovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Boldur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"2024101809064959000_19.3.392.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70230-6"},{"key":"2024101809064959000_19.3.392.2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0891-5520(20)30401-3","volume":"5","year":"1991","journal-title":"Infect Dis Clin North Am"},{"key":"2024101809064959000_19.3.392.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912764"},{"key":"2024101809064959000_19.3.392.4","first-page":"476","volume":"28","year":"1999","journal-title":"Ann Acad Med Singapore"},{"key":"2024101809064959000_19.3.392.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00255-3"},{"key":"2024101809064959000_19.3.392.6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-2-196"},{"key":"2024101809064959000_19.3.392.7","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050161"},{"key":"2024101809064959000_19.3.392.8","first-page":"1243","volume":"109","year":"1995","journal-title":"Chest"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.02.00256702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:13:54Z","timestamp":1740377634000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.02.00256702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,3,1]]},"published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1183\/09031936.02.00256702"],"URL":"https:\/\/doi.org\/10.1183\/09031936.02.00256702","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}