{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:12:18Z","timestamp":1740460338054,"version":"3.37.3"},"reference-count":10,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,4,15]]},"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>Peroxynitrite (ONOO<jats:sup>\u2212<\/jats:sup>) is the reaction product between nitric oxide and the superoxide anion. It is a biological oxidant and cytotoxic anion, produced<jats:italic>in vivo<\/jats:italic>, which might cause inflammation and damage to the lungs. This study was designed to investigate whether direct contact with peroxynitrite could cause pathological changes in the airways.<\/jats:p><jats:p>Twenty New Zealand rabbits were divided into four experimental groups. They were anesthetised by intravascular injection of thiopental sodium, and peroxynitrite (0.5\u2005mL of a 10\u2005mM solution) was inoculated intratracheally. At 2\u2005h, 24\u2005h, 48\u2005h, and 72\u2005h postinoculation trachea and lungs were isolated for histopathology.<\/jats:p><jats:p>The histopathological observations in the lungs were congestion, serous exudation, infiltration of leukocytes and degeneration, which were found to be time-dependent. Changes were similar at 48 and 72\u2005h. Degenerative changes were not progressive. The changes in the trachea were congestion, oedema, leukocyte infiltration, and degeneration of tracheal epithelium.<\/jats:p><jats:p>This study shows that peroxynitrite formation in the respiratory tract induces lung inflammation and degenerative changes.<\/jats:p>","DOI":"10.1183\/09031936.02.00264102","type":"journal-article","created":{"date-parts":[[2002,9,27]],"date-time":"2002-09-27T20:21:23Z","timestamp":1033158083000},"page":"1014-1016","source":"Crossref","is-referenced-by-count":4,"title":["Histopathological studies on the effects of peroxynitrite on the lungs and trachea of rabbits: Fig. 1.\u2014"],"prefix":"10.1183","volume":"20","author":[{"given":"A.A.","family":"Farshid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sadeghi-Hashjin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.R.","family":"Ferdowsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"2024101809485071000_20.4.1014.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00651-0"},{"key":"2024101809485071000_20.4.1014.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00428.x"},{"key":"2024101809485071000_20.4.1014.3","doi-asserted-by":"crossref","first-page":"26066","DOI":"10.1016\/S0021-9258(18)47160-8","volume":"269","year":"1994","journal-title":"J Biol Chem"},{"key":"2024101809485071000_20.4.1014.4","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1016\/S0021-9258(20)64313-7","volume":"266","year":"1991","journal-title":"J Biol Chem"},{"key":"2024101809485071000_20.4.1014.5","doi-asserted-by":"crossref","first-page":"L628","DOI":"10.1152\/ajpcell.1994.266.3.C628","volume":"266","year":"1994","journal-title":"Am J Physiol"},{"key":"2024101809485071000_20.4.1014.6","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1164\/ajrccm.153.5.8630623","volume":"153","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101809485071000_20.4.1014.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14243"},{"key":"2024101809485071000_20.4.1014.8","first-page":"279","volume":"304","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"2024101809485071000_20.4.1014.9","unstructured":"Sadeghi-Hashjin G, Farshid AA, Najjar-Sadeghi B, Kahroba T, Jamshidi A. Microscopic changes in the liver and kidney, induced by peroxynitrite (ONOO\u2212); an in vivo study in the rabbit In: Abstracts: 14th Iranian Congress of Physiol & Pharmacol. Tehran, Tehran University of Medical Sciences, 1999; p.\u2005180."},{"key":"2024101809485071000_20.4.1014.10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09629359891360","volume":"7","year":"1998","journal-title":"Mediator Inflam"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.02.00264102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:47:02Z","timestamp":1740376022000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.02.00264102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2002,10,1]]},"published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1183\/09031936.02.00264102"],"URL":"https:\/\/doi.org\/10.1183\/09031936.02.00264102","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"type":"print","value":"0903-1936"},{"type":"electronic","value":"1399-3003"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}