{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:38:10Z","timestamp":1774125490266,"version":"3.50.1"},"reference-count":41,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,2,19]]},"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>Measurement of cerebral tissue saturation during obstructive sleep apnoea (OSA) may provide additional information to conventional peripheral oxygen saturation.<\/jats:p><jats:p>Thirteen subjects with OSA (mean apnoea\/hypopnoea index 65.7\u00b127.9) were monitored using full polysomnography and monitoring of near-infrared cerebral tissue oxygenation index (TOI). One-thousand and thirty-six apnoeas and hypopnoeas were analysed, in terms of duration, sleep stage, arterial oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>) dip, minimum<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>, TOI dip and minimum TOI. Cerebral TOI is a measure of cerebral tissue saturation of haemoglobin with oxygen, calculated using near-infrared spatially resolved spectroscopy, which has been shown to have a high specificity for intracranial changes.<\/jats:p><jats:p>Decreases in cerebral oxygenation were observed during apnoeas and hypopnoeas. Baseline TOI ranged from 50.1\u201373.0% and mean apnoea\/hypopnoea related TOI dips ranged from 1.43\u20136.85%. Mean<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>dips varied from 3.8\u201321.7%. In regression analysis, factors significantly predicting the magnitude of the TOI dip were<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>dip, minimum<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>, apnoea duration and rapid eye movement sleep stage. The effect of apnoea duration and sleep stage remained significant after<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>was included in the regression equation.<\/jats:p><jats:p>Near-infrared spectroscopy provides a noninvasive technique for monitoring cerebral tissue saturation during obstructive sleep apnoea.<\/jats:p>","DOI":"10.1183\/09031936.02.00265702","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T23:21:54Z","timestamp":1033514514000},"page":"444-450","source":"Crossref","is-referenced-by-count":50,"title":["Some factors affecting cerebral tissue saturation during obstructive sleep apnoea"],"prefix":"10.1183","volume":"20","author":[{"given":"A.","family":"Valipour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"McGown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Makker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.G.","family":"Spiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2024101809412679000_20.2.444.1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1087-0792(99)90014-X","volume":"3","year":"1999","journal-title":"Sleep Medicine Rev"},{"key":"2024101809412679000_20.2.444.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.367"},{"key":"2024101809412679000_20.2.444.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400150068012"},{"key":"2024101809412679000_20.2.444.4","first-page":"686","volume":"1986","year":"1986","journal-title":"Chest"},{"key":"2024101809412679000_20.2.444.5","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1164\/ajrccm.150.6.7952619","volume":"150","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101809412679000_20.2.444.6","unstructured":"Elwell CE. 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