{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:48:51Z","timestamp":1791143331351,"version":"4.1.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,1,16]]},"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>The factors that may modulate ventilatory muscle fatigue during exercise are controversial. In this study the contribution of acidosis to exercise-induced diaphragmatic fatigue was investigated, using measurements of the twitch mouth pressure response (tw,<jats:italic>P<\/jats:italic><jats:sub>mo<\/jats:sub>) to cervical magnetic stimulation.<\/jats:p><jats:p>After learning sessions, 14 healthy subjects performed two cycling tests (at 60% of maximal aerobic power for 16\u2005min), one while breathing spontaneously (mean minute ventilation (<jats:italic>V<\/jats:italic>\u2032e) 67.9\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>) and the other while hypoventilating voluntarily (mean<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub>53.8\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>). Exercise was voluntarily set at a moderate power to avoid a fatiguing effect of exercise<jats:italic>per se<\/jats:italic>.<\/jats:p><jats:p>As compared with spontaneous breathing (SB), voluntary hypoventilation (VHV) significantly increased mean carbon dioxide tension in arterial blood (<jats:italic>P<\/jats:italic><jats:sub>a,CO<jats:sub>2<\/jats:sub><\/jats:sub>) (51\u2005mmHg<jats:italic>versus<\/jats:italic>41\u2005mmHg) and significantly decreased arterial pH (7.28<jats:italic>versus<\/jats:italic>7.34). After 10\u2005min of SB test, tw,<jats:italic>P<\/jats:italic><jats:sub>mo<\/jats:sub>was unchanged compared to the baseline value (19.1<jats:italic>versus<\/jats:italic>18.5\u2005cmH<jats:sub>2<\/jats:sub>O) whereas tw,<jats:italic>P<\/jats:italic><jats:sub>mo<\/jats:sub>fell significantly as compared to baseline (17.1<jats:italic>versus<\/jats:italic>18.5\u2005cmH<jats:sub>2<\/jats:sub>O) and to SB (17.1<jats:italic>versus<\/jats:italic>19.1\u2005cmH<jats:sub>2<\/jats:sub>O) after the VHV test.<\/jats:p><jats:p>The results of this study suggest that exposure to hypercapnia may impair respiratory muscle function. This impairment could be more clinically relevant in patients with chronic obstructive lung disease.<\/jats:p>","DOI":"10.1183\/09031936.02.00268202","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:37:23Z","timestamp":1034361443000},"page":"1079-1086","source":"Crossref","is-referenced-by-count":44,"title":["Contribution of respiratory acidosis to diaphragmatic fatigue at 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