{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:02:58Z","timestamp":1771844578402,"version":"3.50.1"},"reference-count":21,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,6,9]]},"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>In children with mild asthma, who show hardly any abnormalities in pulmonary function, objective measurement of the effect of inhaled corticosteroids is difficult.<\/jats:p><jats:p>The short term effect of fluticasone propionate (FP) in these children was evaluated, using both subjective and objective parameters. A total of 68 children (5\u201310\u2005yrs old) were randomly assigned to either FP 250\u2005\u00b5g or placebo twice daily as metered-dose inhaler<jats:italic>via<\/jats:italic>spacer during 12 weeks. Symptom scores, use of rescue medication, wheezing, parent global evaluation and pulmonary function tests including forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>), peak expiratory flow (PEF) and bronchial responsiveness (provocation dose of methacholine causing a 20% fall in FEV<jats:sub>1<\/jats:sub>(PD<jats:sub>20<\/jats:sub>)) were evaluated.<\/jats:p><jats:p>FP-treated<jats:italic>versus<\/jats:italic>placebo-treated children showed significant changes in percentage symptom-free days, use of \u03b2<jats:sub>2<\/jats:sub>-mimetics, morning and evening PEF, FEV<jats:sub>1<\/jats:sub>% pred and wheezing. No significant improvements were found in parent global evaluation, absolute values of FEV<jats:sub>1<\/jats:sub>nor PD<jats:sub>20<\/jats:sub>.<\/jats:p><jats:p>These findings show that inhaled corticosteroids are effective in children with mild asthma. This effect can be assessed by both objective and subjective parameters. Early start of inhaled corticosteroids should be considered even when pulmonary function is normal.<\/jats:p>","DOI":"10.1183\/09031936.02.00292702","type":"journal-article","created":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T02:27:41Z","timestamp":1041906461000},"page":"1470-1475","source":"Crossref","is-referenced-by-count":23,"title":["Children with mild asthma: do they benefit from inhaled corticosteroids?"],"prefix":"10.1183","volume":"20","author":[{"given":"H.G.M.","family":"Arets","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.W.A.","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.L.","family":"Brackel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.G.H.","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Vermue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.K.","family":"van der Ent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,12,1]]},"reference":[{"key":"2024101809582942000_20.6.1470.1","first-page":"1408","volume":"138","year":"1994","journal-title":"Ned Tijdschr Geneeskd"},{"key":"2024101809582942000_20.6.1470.2","first-page":"868","volume":"332","year":"1997","journal-title":"N Engl J Med"},{"key":"2024101809582942000_20.6.1470.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540350037030"},{"key":"2024101809582942000_20.6.1470.4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1164\/ajrccm\/146.3.547","volume":"146","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2024101809582942000_20.6.1470.5","first-page":"700","volume":"337","year":"1994","journal-title":"N Engl J Med"},{"key":"2024101809582942000_20.6.1470.6","doi-asserted-by":"publisher","DOI":"10.1016\/0954-6111(94)90044-2"},{"key":"2024101809582942000_20.6.1470.7","unstructured":"National Asthma Education and Prevention Program: expert panel report 2. 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