{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:57:43Z","timestamp":1783720663461,"version":"3.55.0"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,2,6]]},"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>Patients with chronic renal failure (CRF) have a high incidence of tuberculosis (TB). Those from the Indian subcontinent are at particular risk. The frequency of side-effects associated with antituberculous treatment in a group of patients with CRF was studied.<\/jats:p><jats:p>All cases of TB in patients with CRF occurring over a 13\u2010yr period at the Manchester Royal Infirmary, from 1986\u20131999, were identified by diagnostic coding, microbiology records and a TB database. The case notes were then reviewed.<\/jats:p><jats:p>Twenty-four cases were identified, eight predialysis and 16 requiring regular dialysis. TB occurring in the dialysis group was extrapulmonary in every case. Nineteen of 24 (79%) patients were of Indian subcontinent origin and 14 of 16 (87%) dialysis patients were non-Caucasian. Adverse effects of treatment occurred in two of eight (25%) in the predialysis group and nine of 16 (56%) of the dialysis group. These were most commonly neuropsychiatric (6), hepatic (4) and gastrointestinal (4). Neuropsychiatric symptoms occurred exclusively in dialysis patients.<\/jats:p><jats:p>In conclusion, a high incidence of side-effects from antituberculous medication, especially neuropsychiatric, hepatic and gastrointestinal, was identified in patients with chronic renal failure. Careful monitoring for side-effects is essential in this group, and consideration should be given to administering antituberculous chemoprophylaxis to all high-risk groups.<\/jats:p>","DOI":"10.1183\/09031936.02.00298002","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T23:21:54Z","timestamp":1033514514000},"page":"440-443","source":"Crossref","is-referenced-by-count":27,"title":["Side-effects of antituberculosis drug treatment in patients with chronic renal failure"],"prefix":"10.1183","volume":"20","author":[{"given":"S.J.","family":"Quantrill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Woodhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gokal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2024101809412108000_20.2.440.1","first-page":"129","volume":"25","year":"1986","journal-title":"Clin Nephrol"},{"key":"2024101809412108000_20.2.440.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90166-7"},{"key":"2024101809412108000_20.2.440.3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000189104","volume":"73","year":"1996","journal-title":"Nephron"},{"key":"2024101809412108000_20.2.440.4","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI106604","volume":"50","year":"1971","journal-title":"J Clin Invest"},{"key":"2024101809412108000_20.2.440.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.7.536"},{"key":"2024101809412108000_20.2.440.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8479(96)90073-8"},{"key":"2024101809412108000_20.2.440.7","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(93)90042-V"},{"key":"2024101809412108000_20.2.440.8","first-page":"444","volume":"27","year":"1993","journal-title":"Ann Pharm"},{"key":"2024101809412108000_20.2.440.9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000187331","volume":"64","year":"1993","journal-title":"Nephron"},{"key":"2024101809412108000_20.2.440.10","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.57.670.492"},{"key":"2024101809412108000_20.2.440.11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/5.8.584"},{"key":"2024101809412108000_20.2.440.12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1980.00330130059017"},{"key":"2024101809412108000_20.2.440.13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.5.1024"},{"key":"2024101809412108000_20.2.440.14","doi-asserted-by":"crossref","unstructured":"Tuberculosis in patients having dialysis (editorial). 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