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Patients who show the greatest reduction in overnight carbon dioxide tension in arterial blood with ventilation are most likely to benefit from long-term ventilatory support.<\/jats:p><jats:p>Some benefits have also been shown in patients with chronic respiratory failure due to bronchiectasis and cystic fibrosis, though survival is inferior in this patient group.<\/jats:p><jats:p>As most studies of noninvasive positive-pressure ventilation in chronic obstructive pulmonary disease have been relatively short term, large multicentre studies with survival, exacerbations and hospital admissions as the primary end points are required to evaluate longer term effects.<\/jats:p>","DOI":"10.1183\/09031936.02.00308502","type":"journal-article","created":{"date-parts":[[2002,9,6]],"date-time":"2002-09-06T21:12:37Z","timestamp":1031346757000},"page":"777-784","source":"Crossref","is-referenced-by-count":34,"title":["Noninvasive ventilation in chronic obstructive pulmonary disease, bronchiectasis and cystic fibrosis"],"prefix":"10.1183","volume":"20","author":[{"given":"J.A.","family":"Wedzicha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F.","family":"Muir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"2024101809462346000_20.3.777.1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.7326\/0003-4819-93-3-391","volume":"93","year":"1980","journal-title":"Ann Intern Med"},{"key":"2024101809462346000_20.3.777.2","first-page":"681","volume":"i","year":"1981","journal-title":"Lancet"},{"key":"2024101809462346000_20.3.777.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.5_Pt_1.905"},{"key":"2024101809462346000_20.3.777.4","first-page":"1","volume":"i","year":"1979","journal-title":"Lancet"},{"key":"2024101809462346000_20.3.777.5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)91166-5"},{"key":"2024101809462346000_20.3.777.6","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1164\/ajrccm\/140.5.1251","volume":"140","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"2024101809462346000_20.3.777.7","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92620-U"},{"key":"2024101809462346000_20.3.777.8","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1164\/ajrccm\/138.6.1515","volume":"138","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"2024101809462346000_20.3.777.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.5.349"},{"key":"2024101809462346000_20.3.777.10","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.5.342"},{"key":"2024101809462346000_20.3.777.11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633704"},{"key":"2024101809462346000_20.3.777.12","doi-asserted-by":"crossref","unstructured":"Douglas NJ. 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