{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:14:05Z","timestamp":1740460445725,"version":"3.37.3"},"reference-count":8,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2001,7,5]]},"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>The pathogenesis of primary pulmonary hypertension is still unclear. The case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6\u2005weeks and died of global cardiac failure is presented.<\/jats:p><jats:p>Autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. Chlamydiae were detected within the pulmonary arteries and in intramural and intra-alveolar macrophages by immunofluorescence, confocal laser scanning microscopy, scanning and transmission electron microscopy. Nested-polymerase chain reaction (PCR) and nonradioactive deoxyribonucleic acid (DNA) hybridization of PCR products from pulmonary arteries revealed<jats:italic>Chlamydia pneumoniae<\/jats:italic>DNA.<\/jats:p><jats:p><jats:italic>Chlamydia pneumoniae<\/jats:italic>has already been detected in atherosclerosis and in pulmonary emphysema. It can induce proliferation of smooth muscle cells.<jats:italic>Chlamydia pneumoniae<\/jats:italic>might be relevant in aggravation of primary pulmonary hypertension and might perhaps be a trigger factor in some cases.<\/jats:p>","DOI":"10.1183\/09031936.02.00682001","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T21:10:12Z","timestamp":1033506612000},"page":"192-194","source":"Crossref","is-referenced-by-count":6,"title":["Detection of<i>Chlamydia pneumoniae<\/i>in unexplained pulmonary hypertension"],"prefix":"10.1183","volume":"19","author":[{"given":"D.","family":"Theegarten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Anhenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Aretz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Maass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mogilevski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"2024101809024138000_19.1.192.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.1.236"},{"key":"2024101809024138000_19.1.192.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.22.2781"},{"key":"2024101809024138000_19.1.192.3","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.4.841"},{"key":"2024101809024138000_19.1.192.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00016-3"},{"key":"2024101809024138000_19.1.192.5","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000242"},{"key":"2024101809024138000_19.1.192.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.18.4.533"},{"key":"2024101809024138000_19.1.192.7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/mr.58.4.686-699.1994","volume":"58","year":"1994","journal-title":"Microbiol Rev"},{"key":"2024101809024138000_19.1.192.8","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1128\/IAI.67.6.2909-2915.1999","volume":"67","year":"1999","journal-title":"Infect Immun"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.02.00682001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:13:38Z","timestamp":1740377618000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.02.00682001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,1,1]]},"published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1183\/09031936.02.00682001"],"URL":"https:\/\/doi.org\/10.1183\/09031936.02.00682001","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"type":"print","value":"0903-1936"},{"type":"electronic","value":"1399-3003"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}