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The contribution of the two potential mechanisms responsible for the hyperventilation seen in the following ICSA was measured: 1) left ventricular diastolic dysfunction-induced pulmonary hypertension; and 2) increased peripheral and central hypercapnic ventilatory responses (HCVR).<\/jats:p><jats:p>The pulmonary artery pressure, left ventricular diastolic function and chemosensitivity to hypercapnia were measured during wakefulness in 16 subjects with ICSA.<\/jats:p><jats:p>All subjects had systolic pulmonary artery pressures &lt;3.99\u2005kPa (&lt;30\u2005mmHg) and only four had diastolic dysfunction. All subjects had elevated peripheral and central HCVR compared with historical normal control subjects. Diastolic dysfunction correlated with increasing age but not with HCVR or markers of central sleep apnoea severity.<\/jats:p><jats:p>Idiopathic nonhypercapnic central sleep apnoea is likely to be dependent upon raised hypercapnic ventilatory responses, and not pulmonary hypertension due to left ventricular diastolic dysfunction.<\/jats:p>","DOI":"10.1183\/09031936.02.00742002","type":"journal-article","created":{"date-parts":[[2002,9,6]],"date-time":"2002-09-06T21:12:37Z","timestamp":1031346757000},"page":"717-723","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac diastolic function and hypercapnic ventilatory responses in central sleep apnoea"],"prefix":"10.1183","volume":"20","author":[{"given":"P.","family":"Solin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Roebuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"2024101809455042000_20.3.717.1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0272-5231(21)00876-5","volume":"13","year":"1992","journal-title":"Clin Chest Med"},{"key":"2024101809455042000_20.3.717.2","first-page":"217","volume":"134","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"2024101809455042000_20.3.717.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.1.104"},{"key":"2024101809455042000_20.3.717.4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756809"},{"key":"2024101809455042000_20.3.717.5","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1164\/ajrccm.152.6.8520761","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101809455042000_20.3.717.6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1183\/09031936.98.11010007","volume":"11","year":"1998","journal-title":"Eur Respir J"},{"key":"2024101809455042000_20.3.717.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411304"},{"key":"2024101809455042000_20.3.717.8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2002024"},{"key":"2024101809455042000_20.3.717.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00214502"},{"key":"2024101809455042000_20.3.717.10","unstructured":"Sackner MA, Kreiger BP. 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