{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:33:21Z","timestamp":1777901601651,"version":"3.51.4"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,4,12]]},"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>Although lung function is grossly normal in patients with primary pulmonary hypertension (PPH), mild-to-moderate peripheral airflow obstruction can be found in the majority of patients with this disease. Therefore, \u03b2<jats:sub>2<\/jats:sub>-agonists may affect pulmonary function, blood gases and haemodynamics in patients with PPH.<\/jats:p><jats:p>Pulmonary function testing, blood gas measurements and right heart catheterisation was performed in 22 patients with PPH and the acute effects of inhaled salbutamol (0.2\u2005mg) were measured.<\/jats:p><jats:p>Salbutamol caused an increase in the forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) from 2446\u00b1704 to 2550\u00b1776\u2005mL. The mean expiratory flow at 50% of the vital capacity (MEF<jats:sub>50<\/jats:sub>) rose from 58\u00b117 to 66\u00b121% pred. The pulmonary artery pressures remained unchanged after inhalation of salbutamol, but the cardiac output increased significantly from 3.9\u00b11.4 to 4.2\u00b11.4\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>accompanied by significant increases in stroke volume and mixed venous oxygen saturation as well as a significant decrease in pulmonary vascular resistance. The arterial oxygen tension rose from 9\u00b12.4\u2005kPa (68\u00b118\u2005mmHg) at baseline to 9.7\u00b12.8\u2005kPa (73\u00b121\u2005mmHg) after inhalation of salbutamol, the alveolo-arterial oxygen gradient values improved from 6\u00b12.5\u2005kPa (45\u00b119\u2005mmHg) to 5.1\u00b12.9\u2005kPa (38\u00b122\u2005mmHg), respectively.<\/jats:p><jats:p>Inhaled salbutamol has beneficial acute effects on pulmonary function, blood gases and haemodynamics in patients with primary pulmonary hypertension.<\/jats:p>","DOI":"10.1183\/09031936.02.02572001","type":"journal-article","created":{"date-parts":[[2002,9,6]],"date-time":"2002-09-06T21:12:37Z","timestamp":1031346757000},"page":"524-528","source":"Crossref","is-referenced-by-count":32,"title":["Effects of inhaled salbutamol in primary pulmonary hypertension"],"prefix":"10.1183","volume":"20","author":[{"given":"E.","family":"Spiekerkoetter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Fabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Hoeper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"2024101809424889000_20.3.524.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360207"},{"key":"2024101809424889000_20.3.524.2","doi-asserted-by":"publisher","DOI":"10.1086\/303059"},{"key":"2024101809424889000_20.3.524.3","doi-asserted-by":"publisher","DOI":"10.1086\/316947"},{"key":"2024101809424889000_20.3.524.4","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.10.741"},{"key":"2024101809424889000_20.3.524.5","unstructured":"Rich S. 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