{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:08:15Z","timestamp":1791083295368,"version":"4.1.0"},"reference-count":21,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2003,6,24]]},"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>The aim of this study was to evaluate the annual prevalence of multidrug-resistant tuberculosis (MDRTB) and to describe the characteristics of the patients with MDRTB in France.<\/jats:p><jats:p>Annual questionnaire surveys from 1992\u20131999 were mailed to all French microbiological laboratories performing mycobacterial cultures. A total of 264 distinct patients were reported to the National Reference Centre for Resistance of Mycobacteria to Antituberculosis Drugs during the 8\u2010yr surveillance period resulting in a mean annual prevalence of MDRTB of 0.6%.<\/jats:p><jats:p>A mean of 16% of the MDRTB patients were reported over several subsequent years. The majority of patients were male (69.7%), foreign-born (55.7%), with a previous history of treatment (65.9%), and pulmonary involvement (92.8%) with smear-positive results (59.1%). Human immunodeficiency virus (HIV) coinfection was present in 20.8% of the patients. Strains were resistant only to isoniazid and rifampin in 37.9% of the cases, and additional resistance to both streptomycin and ethambutol was present in 25.8%. HIV coinfection and female status were statistically associated with primary resistance, whereas smear-positive results were associated with secondary resistance. Foreign-birth and smear-positive results were associated with a chronic status.<\/jats:p><jats:p>The prevalence of multidrug-resistant tuberculosis is low in France (&lt;1%). However, a substantial proportion of patients remain positive for several years, suggesting nonoptimal management. Therefore, as recommended by the World Health Organization, a few reference teams, working in collaboration with national associations of physicians and microbiologists, should be established to improve the outcome of multidrug-resistant tuberculosis.<\/jats:p>","DOI":"10.1183\/09031936.03.00014103","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T21:10:15Z","timestamp":1067461815000},"page":"833-837","source":"Crossref","is-referenced-by-count":34,"title":["Multidrug-resistant tuberculosis: eight years of surveillance in France"],"prefix":"10.1183","volume":"22","author":[{"given":"J.","family":"Robert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Trystram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Truffot-Pernot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Jarlier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"2024101810351554000_22.5.833.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104263441706"},{"key":"2024101810351554000_22.5.833.2","first-page":"423","volume":"133","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"2024101810351554000_22.5.833.3","first-page":"587","volume":"166","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101810351554000_22.5.833.4","unstructured":"World Health OrganizationGlobal tuberculosis control. 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