{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:52:40Z","timestamp":1772225560144,"version":"3.50.1"},"reference-count":8,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,8,5]]},"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>The case of a 49-yr-old female, who developed fever, effort dyspnoea and cough, with patchy migratory bilateral pulmonary infiltrates 6 weeks after starting transtuzumab therapy, following breast-conserving surgery with adjuvant chemoradiotherapy and hormone therapy for breast carcinoma, is reported here.<\/jats:p><jats:p>Chest radiograph and thin section computed tomography demonstrated alveolar opacities with air bronchogram in both lungs. A lung biopsy was performed in a nonirradiated area of the contralateral lung and revealed a typical histological pattern of organising pneumonia (previously known as bronchiolitis obliterans organising pneumonia). Transtuzumab therapy was discontinued and subsequent gradual clinical and radiological improvement was observed. After 3 months, complete resolution of symptoms and radiographical abnormalities were noted.<\/jats:p><jats:p>This is the first case report that suggests that transtuzumab therapy might induce the development of lung infiltrates with the histological appearance of organising pneumonia.<\/jats:p>","DOI":"10.1183\/09031936.03.00035502","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:25:02Z","timestamp":1221845102000},"page":"552-555","source":"Crossref","is-referenced-by-count":49,"title":["Organising pneumonia caused by transtuzumab (Herceptin) therapy for breast cancer"],"prefix":"10.1183","volume":"21","author":[{"given":"E.","family":"Radzikowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Szczepulska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chabowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bestry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2024101810073908000_21.3.552.1","first-page":"1","volume":"1","year":"2001","journal-title":"Semin Oncol"},{"key":"2024101810073908000_21.3.552.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08020322"},{"key":"2024101810073908000_21.3.552.3","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1164\/ajrccm.158.6.9711036","volume":"158","year":"1998","journal-title":"Am J Respir Dis"},{"key":"2024101810073908000_21.3.552.4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440330057006"},{"key":"2024101810073908000_21.3.552.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.1.8S"},{"key":"2024101810073908000_21.3.552.6","doi-asserted-by":"publisher","DOI":"10.4065\/74.1.27"},{"key":"2024101810073908000_21.3.552.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.1.14S"},{"key":"2024101810073908000_21.3.552.8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000055403","volume":"61","year":"2001","journal-title":"Oncology"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.03.00035502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:17:13Z","timestamp":1740377833000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.03.00035502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,3,1]]},"published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1183\/09031936.03.00035502"],"URL":"https:\/\/doi.org\/10.1183\/09031936.03.00035502","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}