{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:35:58Z","timestamp":1775507758120,"version":"3.50.1"},"reference-count":20,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,11,11]]},"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>The utilisation of nocturnal wheeze monitoring and quantification for assessment of asthma activity was studied in symptomatic school-aged children before and during treatment.<\/jats:p><jats:p>Twelve children 6\u201314\u2005yrs of age with mild or moderate untreated asthma were studied\u00a0at home three times: before, 48\u2005h and 6 weeks into treatment with 5\u2005mg montelukast daily. Lung sounds were recorded overnight by an automatic wheeze detection device (PulmoTrack\u00ae). Per cent wheezing within each respiratory cycle was calculated every 30\u2005s throughout the night and a Nocturnal Wheeze Index (NWI) was calculated for the total night. The results were compared with spirometric indices (forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>), forced vital capacity), bronchial reactivity (provocative concentration causing a 20% fall in FEV<jats:sub>1<\/jats:sub>by adenosine 5\u2032-monophosphate (PC<jats:sub>20<\/jats:sub>)) and daily symptom scores, performed in parallel at each stage of the study.<\/jats:p><jats:p>The pretreatment NWI was 814\u00b1898 (mean\u00b1sd), which declined to 318\u00b1199 2 days after onset, and to 137\u00b1101 after 6 weeks of treatment. The NWI in seven healthy children was 47\u00b143. The FEV<jats:sub>1<\/jats:sub>, PC<jats:sub>20<\/jats:sub>and symptom scores improved in parallel.<\/jats:p><jats:p>Wheeze monitoring provides quantitative and noninvasive information about the extent of nocturnal wheezing in children, correlates well with conventional indices of asthma activity and can assist in assessing efficacy of treatment.<\/jats:p>","DOI":"10.1183\/09031936.03.00036302","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:25:02Z","timestamp":1221845102000},"page":"621-626","source":"Crossref","is-referenced-by-count":59,"title":["Wheeze monitoring in children for assessment of nocturnal asthma and response to therapy"],"prefix":"10.1183","volume":"21","author":[{"given":"L.","family":"Bentur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shinawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Naveh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Gavriely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"2024101810100455000_21.4.621.1","first-page":"6","volume":"85","year":"1988","journal-title":"Am J Med"},{"key":"2024101810100455000_21.4.621.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08122076"},{"key":"2024101810100455000_21.4.621.3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.5.413"},{"key":"2024101810100455000_21.4.621.4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.4.9701001"},{"key":"2024101810100455000_21.4.621.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.8.600"},{"key":"2024101810100455000_21.4.621.6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1152\/jappl.1989.67.1.243","volume":"67","year":"1989","journal-title":"J Appl Physiol"},{"key":"2024101810100455000_21.4.621.7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ppul.1950150405","volume":"15","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"2024101810100455000_21.4.621.8","unstructured":"Kercsmar CM.. Asthma In: Chernick V, Boat TF, editors. Disorders of the Respiratory Tract in ChildrenPhiladelphia, Saunders Co., 1999; p. 688."},{"key":"2024101810100455000_21.4.621.9","first-page":"191","volume":"22","year":"1986","journal-title":"Bull\u00a0Eur Physiopathol Respir"},{"key":"2024101810100455000_21.4.621.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.1999.00150.x"},{"key":"2024101810100455000_21.4.621.11","unstructured":"National Institute of Health. Global Initiative for Asthma: (GINA) \u2013 the new GINA workshop report 2002. National Heart Lung and Blood Institute\/World Health Organization Workshop ReportBethesda, MD, National Institute of Health, 2002."},{"key":"2024101810100455000_21.4.621.12","unstructured":"Gavriely N.. Breath Sounds MethodologyBoca Raton, CRC Press, 1995; pp. 55\u201397."},{"key":"2024101810100455000_21.4.621.13","first-page":"585","volume":"10","year":"2000","journal-title":"Eur Respir Rev"},{"key":"2024101810100455000_21.4.621.14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.3.364"},{"key":"2024101810100455000_21.4.621.15","first-page":"147","volume":"14","year":"1999","journal-title":"Eur Respir J"},{"key":"2024101810100455000_21.4.621.16","first-page":"72","volume":"14","year":"1999","journal-title":"Eur Respir J"},{"key":"2024101810100455000_21.4.621.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70079-X"},{"key":"2024101810100455000_21.4.621.18","first-page":"50","volume":"32","year":"1985","journal-title":"IEEE Trans Biomed Eng"},{"key":"2024101810100455000_21.4.621.19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1152\/jappl.1984.57.2.481","volume":"57","year":"1984","journal-title":"J Appl Physiol"},{"key":"2024101810100455000_21.4.621.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.15.1181"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.03.00036302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:17:27Z","timestamp":1740377847000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.03.00036302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,4,1]]},"published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1183\/09031936.03.00036302"],"URL":"https:\/\/doi.org\/10.1183\/09031936.03.00036302","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}